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Tbio
PAX8
Paired box protein Pax-8

Protein Summary
Description
Transcription factor for the thyroid-specific expression of the genes exclusively expressed in the thyroid cell type, maintaining the functional differentiation of such cells. This gene encodes a member of the paired box (PAX) family of transcription factors. Members of this gene family typically encode proteins that contain a paired box domain, an octapeptide, and a paired-type homeodomain. This nuclear protein is involved in thyroid follicular cell development and expression of thyroid-specific genes. Mutations in this gene have been associated with thyroid dysgenesis, thyroid follicular carcinomas and atypical follicular thyroid adenomas. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Mar 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000263334
  • ENSP00000263334
  • ENSG00000125618
  • ENST00000263335
  • ENSP00000263335
  • ENST00000348715
  • ENSP00000314750
  • ENST00000397647
  • ENSP00000380768
  • ENST00000429538
  • ENSP00000395498
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
co-expressed gene
0.97
molecular function
0.88
disease perturbation
0.87
biological term
0.86


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 737.63   (req: < 5)
Gene RIFs: 152   (req: <= 3)
Antibodies: 780   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 737.63   (req: >= 5)
Gene RIFs: 152   (req: > 3)
Antibodies: 780   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 42
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sleep duration
2
2
2
90.8
blood urea nitrogen measurement
3
2
3
89.2
1
1
0
1.2
70.9
1
1
0
1.1
60
renal system measurement
1
1
1
45.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sleep duration
2
90.8
blood urea nitrogen measurement
3
89.2
0
1.2
70.9
0
1.1
60
renal system measurement
1
45.5
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (7)
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
KEGG
Transcriptional misregulation in cancer
KEGG
Pathways in cancer
KEGG
Thyroid cancer
KEGG
Thyroid hormone synthesis
Name
Explore in Pharos
Explore in Source
Transcriptional misregulation in cancer
Pathways in cancer
Thyroid cancer
Thyroid hormone synthesis
Gene Ontology Terms (44)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (126)
1 – 10 of 126
PPARG
Tclin
Family: NR
Novelty: 0.00010033
Score: 0.932
Data Source: STRINGDB
NKX2-1
Tbio
Family: TF
Novelty: 0.00077491
Score: 0.883
Data Source: STRINGDB
FOXE1
Tbio
Family: TF
Novelty: 0.00783938
Score: 0.879
Data Source: STRINGDB
RXRG
Tclin
Family: NR
Novelty: 0.01646377
Score: 0.84
Data Source: STRINGDB
RXRB
Tclin
Family: NR
Novelty: 0.01503977
Score: 0.839
Data Source: STRINGDB
RXRA
Tclin
Family: NR
Novelty: 0.00244343
Score: 0.834
Data Source: STRINGDB
PRKACG
Tbio
Family: Kinase
Novelty: 0.11080061
Score: 0.82
Data Source: STRINGDB
PRKACA
Tchem
Family: Kinase
Novelty: 0.03869658
Score: 0.82
Data Source: STRINGDB
PRKACB
Tchem
Family: Kinase
Novelty: 0.01962222
Score: 0.82
Data Source: STRINGDB
TG
Tbio
Novelty: 0.00010111
Score: 0.803
Data Source: STRINGDB
Publication Statistics
PubMed Score  737.63

PubMed score by year
PubTator Score  407.52

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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