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Tclin
TYR
Tyrosinase

Protein Summary
Description
This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds. Catalyzes the initial and rate limiting step in the cascade of reactions leading to melanin production from tyrosine. In addition to hydroxylating tyrosine to DOPA (3,4-dihydroxyphenylalanine), also catalyzes the oxidation of DOPA to DOPA-quinone, and possibly the oxidation of DHI (5,6-dihydroxyindole) to indole-5,6 quinone. The enzyme encoded by this gene catalyzes the first 2 steps, and at least 1 subsequent step, in the conversion of tyrosine to melanin. The enzyme has both tyrosine hydroxylase and dopa oxidase catalytic activities, and requires copper for function. Mutations in this gene result in oculocutaneous albinism, and nonpathologic polymorphisms result in skin pigmentation variation. The human genome contains a pseudogene similar to the 3' half of this gene. [provided by RefSeq, Oct 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000263321
  • ENSP00000263321
  • ENSG00000077498

Symbol
  • ATN
  • CMM8
  • OCA1
  • OCA1A
  • OCAIA
  • SHEP3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
0.97
chemical
0.85
virus perturbation
0.85
disease
0.81
kinase perturbation
0.81


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1941.41   (req: < 5)
Gene RIFs: 114   (req: <= 3)
Antibodies: 774   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1941.41   (req: >= 5)
Gene RIFs: 114   (req: > 3)
Antibodies: 774   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 15
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3
GWAS Traits (25)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
suntan
3
2
3
97.1
4
2
0
1.2
96
2
2
0
1.5
94.9
hair colour measurement
1
1
1
89.7
cutaneous squamous cell carcinoma
2
1
1
1.2
89.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
suntan
3
97.1
0
1.2
96
0
1.5
94.9
hair colour measurement
1
89.7
cutaneous squamous cell carcinoma
1
1.2
89.3
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
tyrosinase
VGNC:956
451473
Macaque
tyrosinase
705792
Mouse
MGI:98880
22173
Rat
RGD:1589755
308800
Dog
tyrosinase
VGNC:48026
403405
Species
Name
OMA
EggNOG
Inparanoid
Chimp
tyrosinase
Macaque
tyrosinase
Mouse
Rat
Dog
tyrosinase
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P14679-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (12)
Melanin biosynthesis (R-HSA-5662702)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Melanin biosynthesis
Reactome
Metabolism
Reactome
Metabolism of amino acids and derivatives
Name
Explore in Pharos
Explore in Source
Melanin biosynthesis
Metabolism
Metabolism of amino acids and derivatives
Gene Ontology Terms (25)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Protein-Protein Interactions (157)
1 – 10 of 157
DCT
Tbio
Family: Enzyme
Novelty: 0.00411451
Score: 0.982
Data Source: STRINGDB
PMEL
Tbio
Novelty: 0.00116525
Score: 0.98
Data Source: STRINGDB
MLANA
Tbio
Novelty: 0.00070835
Score: 0.975
Data Source: STRINGDB
MITF
Tbio
Family: TF
Novelty: 0.00094044
Score: 0.962
Data Source: STRINGDB
TH
Tclin
Family: Enzyme
Novelty: 0.00025719
Score: 0.962
Data Source: STRINGDB
DDC
Tclin
Family: Enzyme
Novelty: 0.0012284
Score: 0.945
Data Source: STRINGDB
OCA2
Tbio
Novelty: 0.00249611
Score: 0.934
Data Source: STRINGDB
TRPC1
Tbio
Family: IC
Novelty: 0.00233677
Score: 0.919
Data Source: STRINGDB
PAH
Tclin
Family: Enzyme
Novelty: 0.00337068
Score: 0.917
Data Source: STRINGDB
TPO
Tclin
Family: Enzyme
Novelty: 0.00085969
Score: 0.914
Data Source: STRINGDB
Publication Statistics
PubMed Score  1941.41

PubMed score by year
PubTator Score  3434.96

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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