You are using an outdated browser. Please upgrade your browser to improve your experience.

Tchem
NOX4
NADPH oxidase 4

Protein Summary
Description
Constitutive NADPH oxidase which generates superoxide intracellularly upon formation of a complex with CYBA/p22phox. Regulates signaling cascades probably through phosphatases inhibition. May function as an oxygen sensor regulating the KCNK3/TASK-1 potassium channel and HIF1A activity. May regulate insulin signaling cascade. May play a role in apoptosis, bone resorption and lipolysaccharide-mediated activation of NFKB. May produce superoxide in the nucleus and play a role in regulating gene expression upon cell stimulation. Isoform 3 is not functional. Isoform 5 and isoform 6 display reduced activity. Isoform 4: Involved in redox signaling in vascular cells. Constitutively and NADPH-dependently generates reactive oxygen species (ROS). Modulates the nuclear activation of ERK1/2 and the ELK1 transcription factor, and is capable of inducing nuclear DNA damage. Displays an increased activity relative to isoform 1. This gene encodes a member of the NOX-family of enzymes that functions as th ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000263317
  • ENSP00000263317
  • ENSG00000086991
  • ENST00000343727
  • ENSP00000344747
  • ENST00000375979
  • ENSP00000365146
  • ENST00000393282
  • ENSP00000376961
  • ENST00000424319
  • ENSP00000412446
  • ENST00000527956
  • ENSP00000433797
  • ENST00000529343
  • ENSP00000435474
  • ENST00000531342
  • ENSP00000435039
  • ENST00000532825
  • ENSP00000434924
  • ENST00000534731
  • ENSP00000436892

Symbol
  • RENOX
  • KOX
  • KOX-1
  • RENOX
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.99
cellular component
0.93
protein domain
0.85
molecular function
0.81
disease
0.78


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1214.66   (req: < 5)
Gene RIFs: 260   (req: <= 3)
Antibodies: 574   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1214.66   (req: >= 5)
Gene RIFs: 260   (req: > 3)
Antibodies: 574   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 38
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 62
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
quercetin
chemical structure image
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
homocysteine measurement
1
2
2
89.1
suntan
1
1
1
79.5
pulse pressure measurement
2
1
3
68.7
1
1
0
1.6
66.5
1
1
0
1.6
66.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
homocysteine measurement
2
89.1
suntan
1
79.5
pulse pressure measurement
3
68.7
0
1.6
66.5
0
1.6
66.5
Pathways (7)
Cellular responses to external stimuli (R-HSA-8953897)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cellular responses to external stimuli
Reactome
Cellular responses to stress
Reactome
Detoxification of Reactive Oxygen Species
Name
Explore in Pharos
Explore in Source
Cellular responses to external stimuli
Cellular responses to stress
Detoxification of Reactive Oxygen Species
Gene Ontology Terms (49)
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
ARUK-UCL
Traceable Author Statement (TAS)
UniProtKB
Traceable Author Statement (TAS)
UniProtKB
Traceable Author Statement (TAS)
UniProtKB
Traceable Author Statement (TAS)
UniProtKB
Traceable Author Statement (TAS)
UniProtKB
Traceable Author Statement (TAS)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Protein-Protein Interactions (144)
1 – 10 of 144
ACTBL2
Tbio
Novelty: 0.18080702
p_int: 0.84468175
p_ni: 0.15531825
Score: 0.156
Data Source: BioPlex,STRINGDB
MYO18A
Tbio
Novelty: 0.05058328
p_int: 0.765932557
p_ni: 0.234067443
Score: 0.199
Data Source: BioPlex,STRINGDB
CYBA
Tbio
Novelty: 0.00177762
Score: 0.994
Data Source: Reactome,STRINGDB
PTPN1
Tchem
Family: Enzyme
Novelty: 0.00065779
Score: 0.949
Data Source: STRINGDB
DECR1
Tbio
Family: Enzyme
Novelty: 0.02699187
Score: 0.943
Data Source: STRINGDB
NCF1
Tbio
Novelty: 0.00120288
Score: 0.933
Data Source: STRINGDB
NCF2
Tbio
Novelty: 0.00274685
Score: 0.92
Data Source: STRINGDB
CYBB
Tchem
Family: IC
Novelty: 0.00054866
Score: 0.913
Data Source: Reactome,STRINGDB
TLR4
Tchem
Novelty: 0.00010863
Score: 0.865
Data Source: STRINGDB
AGER
Tchem
Novelty: 0.00061101
Score: 0.845
Data Source: STRINGDB
Publication Statistics
PubMed Score  1214.66

PubMed score by year
PubTator Score  511.96

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: