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Tbio
DGCR2
Integral membrane protein DGCR2/IDD

Protein Summary
Description
Putative adhesion receptor, that could be involved in cell-cell or cell-matrix interactions required for normal cell differentiation and migration. Deletions of the 22q11.2 have been associated with a wide range of developmental defects (notably DiGeorge syndrome, velocardiofacial syndrome, conotruncal anomaly face syndrome and isolated conotruncal cardiac defects) classified under the acronym CATCH 22. The DGCR2 gene encodes a novel putative adhesion receptor protein, which could play a role in neural crest cells migration, a process which has been proposed to be altered in DiGeorge syndrome. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000263196
  • ENSP00000263196
  • ENSG00000070413
  • ENST00000537045
  • ENSP00000440062

Symbol
  • IDD
  • KIAA0163
  • IDD
  • LAN
  • DGS-C
  • SEZ-12
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.85
disease perturbation
0.74
transcription factor perturbation
0.74
tissue sample
0.68
cell type or tissue
0.66


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.42   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 147   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.42   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 147   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (3)
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
WikiPathways
22q11.2 Deletion Syndrome
WikiPathways
22q11.2 Deletion Syndrome
WikiPathways
22q11.2 Deletion Syndrome
Name
Explore in Pharos
Explore in Source
22q11.2 Deletion Syndrome
22q11.2 Deletion Syndrome
22q11.2 Deletion Syndrome
Gene Ontology Terms (5)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (33)
1 – 10 of 33
ADAM33
Tchem
Family: Enzyme
Novelty: 0.00584097
p_int: 0.917796548
p_ni: 0.082203452
Score: 0.199
Data Source: BioPlex,STRINGDB
HIRA
Tbio
Novelty: 0.01362595
Score: 0.759
Data Source: STRINGDB
ESS2
Tbio
Novelty: 0.00163665
Score: 0.754
Data Source: STRINGDB
ZDHHC8
Tbio
Family: Enzyme
Novelty: 0.03434357
Score: 0.679
Data Source: STRINGDB
GP1BB
Tbio
Novelty: 0.01235173
Score: 0.671
Data Source: STRINGDB
SLC25A1
Tbio
Family: Transporter
Novelty: 0.00547533
Score: 0.656
Data Source: STRINGDB
ADI1
Tbio
Family: Enzyme
Novelty: 0.00908955
Score: 0.654
Data Source: STRINGDB
TBX1
Tbio
Family: TF
Novelty: 0.00154882
Score: 0.644
Data Source: STRINGDB
DGCR6
Tbio
Novelty: 0.1511746
Score: 0.641
Data Source: STRINGDB
DGCR6L
Tbio
Novelty: 0.11554203
Score: 0.641
Data Source: STRINGDB
Publication Statistics
PubMed Score  16.42

PubMed score by year
PubTator Score  46.84

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer