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Tbio
MSH4
MutS protein homolog 4

Protein Summary
Description
Involved in meiotic recombination. Required for reciprocal recombination and proper segregation of homologous chromosomes at meiosis. This gene encodes a member of the DNA mismatch repair mutS family. This member is a meiosis-specific protein that is not involved in DNA mismatch correction, but is required for reciprocal recombination and proper segregation of homologous chromosomes at meiosis I. This protein and MSH5 form a heterodimer which binds uniquely to a Holliday Junction and its developmental progenitor, thus provoking ADP-ATP exchange, and stabilizing the interaction between parental chromosomes during meiosis double-stranded break repair. [provided by RefSeq, Aug 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000263187
  • ENSP00000263187
  • ENSG00000057468
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.98
gene perturbation
0.85
virus perturbation
0.83
protein domain
0.73
cellular component
0.66


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IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 114.23   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 139   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 114.23   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 139   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
mutS homolog 4
VGNC:1334
469357
Macaque
mutS homolog 4
705294
Mouse
MGI:1860077
55993
Rat
RGD:1309190
295541
Dog
mutS homolog 4
VGNC:43440
612681
Species
Name
OMA
EggNOG
Inparanoid
Chimp
mutS homolog 4
Macaque
mutS homolog 4
Mouse
Rat
Dog
mutS homolog 4
Pathways (4)
Cell Cycle (R-HSA-1640170)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell Cycle
Reactome
Meiosis
Reactome
Meiotic recombination
Reactome
Reproduction
Name
Explore in Pharos
Explore in Source
Cell Cycle
Meiosis
Meiotic recombination
Reproduction
Gene Ontology Terms (18)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (155)
1 – 10 of 155
MLH1
Tbio
Novelty: 0.00034212
Score: 0.998
Data Source: STRINGDB
MLH3
Tbio
Novelty: 0.01295793
Score: 0.997
Data Source: STRINGDB
RAD51
Tchem
Novelty: 0.00011516
Score: 0.988
Data Source: STRINGDB
TOP3A
Tbio
Family: Enzyme
Novelty: 0.0055546
Score: 0.975
Data Source: STRINGDB
MSH5
Tbio
Novelty: 0.0109825
Score: 0.974
Data Source: Reactome,STRINGDB
BLM
Tchem
Novelty: 0.00662454
Score: 0.969
Data Source: STRINGDB
HIST1H2BD
Tbio
Novelty: 0.05094332
Score: 0.969
Data Source: STRINGDB
DMC1
Tbio
Novelty: 0.05445277
Score: 0.967
Data Source: STRINGDB
RPA1
Tchem
Novelty: 0.00212665
Score: 0.961
Data Source: STRINGDB
HFM1
Tbio
Family: Enzyme
Novelty: 0.01556527
Score: 0.943
Data Source: STRINGDB
Publication Statistics
PubMed Score  114.23

PubMed score by year
PubTator Score  32.53

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer