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Tbio
SLC17A6
Vesicular glutamate transporter 2

Protein Summary
Description
Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. May also mediate the transport of inorganic phosphate.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000263160
  • ENSP00000263160
  • ENSG00000091664

Symbol
  • DNPI
  • VGLUT2
  • DNPI
  • VGLUT2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cellular component
0.71
gene perturbation
0.63
molecular function
0.63
cell line
0.59
disease
0.57


Related Tools
RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 690.22   (req: < 5)
Gene RIFs: 15   (req: <= 3)
Antibodies: 212   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 690.22   (req: >= 5)
Gene RIFs: 15   (req: > 3)
Antibodies: 212   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 17 member 6
VGNC:7758
100610704
Macaque
solute carrier family 17 member 6
100425977
Mouse
MGI:2156052
140919
Rat
RGD:620531
84487
Dog
solute carrier family 17 member 6
VGNC:46251
100316859
Species
Name
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 17 member 6
Macaque
solute carrier family 17 member 6
Mouse
Rat
Dog
solute carrier family 17 member 6
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9P2U8-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (10)
Organic anion transporters (R-HSA-428643)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Organic anion transporters
Reactome
SLC-mediated transmembrane transport
Reactome
Transport of inorganic cations/anions and amino acids/oligopeptides
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
Organic anion transporters
SLC-mediated transmembrane transport
Transport of inorganic cations/anions and amino acids/oligopeptides
Transport of small molecules
Protein-Protein Interactions (171)
1 – 10 of 171
SLC32A1
Tchem
Family: Transporter
Novelty: 0.00237273
Score: 0.987
Data Source: STRINGDB
SLC18A3
Tchem
Family: Transporter
Novelty: 0.00169007
Score: 0.958
Data Source: STRINGDB
SLC18A2
Tclin
Family: Transporter
Novelty: 0.00072341
Score: 0.919
Data Source: STRINGDB
SLC18A1
Tchem
Family: Transporter
Novelty: 0.01135292
Score: 0.882
Data Source: STRINGDB
GAD2
Tbio
Family: Enzyme
Novelty: 0.00058427
Score: 0.86
Data Source: STRINGDB
GAD1
Tbio
Family: Enzyme
Novelty: 0.00067443
Score: 0.843
Data Source: STRINGDB
SLC17A7
Tbio
Family: Transporter
Novelty: 0.00165722
Score: 0.838
Data Source: STRINGDB
SLC17A8
Tbio
Family: Transporter
Novelty: 0.00647654
Score: 0.811
Data Source: STRINGDB
SYP
Tbio
Novelty: 0.00021543
Score: 0.774
Data Source: STRINGDB
SYN1
Tbio
Novelty: 0.00093242
Score: 0.75
Data Source: STRINGDB
Publication Statistics
PubMed Score  690.22

PubMed score by year
PubTator Score  132.49

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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