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Tclin
KCNQ4
Potassium voltage-gated channel subfamily KQT member 4

Protein Summary
Description
Probably important in the regulation of neuronal excitability. May underlie a potassium current involved in regulating the excitability of sensory cells of the cochlea. KCNQ4 channels are blocked by linopirdin, XE991 and bepridil, whereas clofilium is without significant effect. Muscarinic agonist oxotremorine-M strongly suppress KCNQ4 current in CHO cells in which cloned KCNQ4 channels were coexpressed with M1 muscarinic receptors. The protein encoded by this gene forms a potassium channel that is thought to play a critical role in the regulation of neuronal excitability, particularly in sensory cells of the cochlea. The current generated by this channel is inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anti-convulsant drug. The encoded protein can form a homomultimeric potassium channel or possibly a heteromultimeric channel in association with the protein encoded by the KCNQ3 gene. Defects in this gene are a cause of nonsyndromic sensorineura ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000347132
  • ENSP00000262916
  • ENSG00000117013
  • ENST00000509682
  • ENSP00000423756
  • ENST00000642618
  • ENSP00000494128

Symbol
  • DFNA2
  • KV7.4
  • DFNA2A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.85
molecular function
0.79
microRNA
0.69
transcription factor
0.65
cellular component
0.63


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 121.29   (req: < 5)
Gene RIFs: 47   (req: <= 3)
Antibodies: 333   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 121.29   (req: >= 5)
Gene RIFs: 47   (req: > 3)
Antibodies: 333   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 10
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 5
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (4)
Neuronal System (R-HSA-112316)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Neuronal System
Reactome
Potassium Channels
Reactome
Voltage gated Potassium channels
Name
Explore in Pharos
Explore in Source
Neuronal System
Potassium Channels
Voltage gated Potassium channels
Gene Ontology Terms (13)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (157)
1 – 10 of 157
KCNAB1
Tbio
Family: IC
Novelty: 0.01799224
Score: 0.947
Data Source: STRINGDB
KCNAB2
Tbio
Family: IC
Novelty: 0.02072106
Score: 0.944
Data Source: STRINGDB
KCNAB3
Tbio
Family: IC
Novelty: 0.16424117
Score: 0.924
Data Source: STRINGDB
KCNQ3
Tclin
Family: IC
Novelty: 0.00715172
Score: 0.882
Data Source: STRINGDB
KCNJ4
Tchem
Family: IC
Novelty: 0.01160219
Score: 0.868
Data Source: STRINGDB
KCNJ12
Tchem
Family: IC
Novelty: 0.01190041
Score: 0.855
Data Source: STRINGDB
KCNJ2
Tchem
Family: IC
Novelty: 0.0039797
Score: 0.853
Data Source: STRINGDB
KCNQ1
Tclin
Family: IC
Novelty: 0.00103494
Score: 0.826
Data Source: STRINGDB
KCNQ2
Tclin
Family: IC
Novelty: 0.00258379
Score: 0.816
Data Source: STRINGDB
KCNQ5
Tclin
Family: IC
Novelty: 0.01899472
Score: 0.808
Data Source: STRINGDB
Publication Statistics
PubMed Score  121.29

PubMed score by year
PubTator Score  103.63

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer