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Tbio
BPI
Bactericidal permeability-increasing protein

Protein Summary
Description
The cytotoxic action of BPI is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope. Has antibacterial activity against the Gram-negative bacterium P.aeruginosa, this activity is inhibited by LPS from P.aeruginosa. This gene encodes a lipopolysaccharide binding protein. It is associated with human neutrophil granules and has antimicrobial activity against gram-negative organisms. [provided by RefSeq, Nov 2014]
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.84
protein domain
0.73
tissue sample
0.59
biological term
0.57
cellular component
0.57


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 397.47   (req: < 5)
Gene RIFs: 35   (req: <= 3)
Antibodies: 311   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 397.47   (req: >= 5)
Gene RIFs: 35   (req: > 3)
Antibodies: 311   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte percentage of leukocytes
1
1
1
33.1
basophil count
1
1
1
1.6
basophil percentage of leukocytes
1
1
1
1.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte percentage of leukocytes
1
33.1
basophil count
1
1.6
basophil percentage of leukocytes
1
1.5
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (6)
Antimicrobial peptides (R-HSA-6803157)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Antimicrobial peptides
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Neutrophil degranulation
Reactome
Toll Like Receptor 4 (TLR4) Cascade
Name
Explore in Pharos
Explore in Source
Antimicrobial peptides
Immune System
Innate Immune System
Neutrophil degranulation
Toll Like Receptor 4 (TLR4) Cascade
Gene Ontology Terms (17)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Protein-Protein Interactions (162)
1 – 10 of 162
DEFA4
Tbio
Novelty: 0.04566082
Score: 0.984
Data Source: STRINGDB
MPO
Tchem
Family: Enzyme
Novelty: 0.00020698
Score: 0.983
Data Source: STRINGDB
ELANE
Tclin
Family: Enzyme
Novelty: 0.00026112
Score: 0.982
Data Source: STRINGDB
AZU1
Tbio
Family: Enzyme
Novelty: 0.00267169
Score: 0.982
Data Source: STRINGDB
CTSG
Tchem
Family: Enzyme
Novelty: 0.00102052
Score: 0.974
Data Source: STRINGDB
CAMP
Tbio
Novelty: 0.00064433
Score: 0.974
Data Source: STRINGDB
PRTN3
Tchem
Family: Enzyme
Novelty: 0.00022728
Score: 0.972
Data Source: STRINGDB
PGLYRP1
Tbio
Novelty: 0.00231527
Score: 0.96
Data Source: STRINGDB
RNASE3
Tbio
Family: Enzyme
Novelty: 0.00059878
Score: 0.94
Data Source: STRINGDB
LTF
Tbio
Novelty: 0.00114254
Score: 0.939
Data Source: STRINGDB
Publication Statistics
PubMed Score  397.47

PubMed score by year
PubTator Score  460.29

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
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