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Tbio
MOV10L1
RNA helicase Mov10l1

Protein Classes
Protein Summary
Description
ATP-dependent RNA helicase required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Involved in the primary piRNA metabolic process. Specifically binds to piRNA precursors and promotes the generation of intermediate piRNA processing fragments that are subsequently loaded to Piwi proteins. Acts via its ATP-dependent RNA helicase activity: displays 5'-3' RNA unwinding activity and probably mediates unwinding and funneling of single-stranded piRNA precursor transcripts to the endonuclease that catalyzes the first cleavage step of piRNA processing to generate piRNA intermediate fragments that are subsequently loaded to Piwi proteins. This gene is similar to a mouse gene that e ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262794
  • ENSP00000262794
  • ENSG00000073146
  • ENST00000354853
  • ENSP00000346917
  • ENST00000395852
  • ENSP00000379193
  • ENST00000395858
  • ENSP00000379199
  • ENST00000540615
  • ENSP00000438542
  • ENST00000545383
  • ENSP00000438978

Symbol
  • CHAMP
  • DJ402G11.8
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.99
transcription factor
0.63
cell type or tissue
0.62
tissue sample
0.52
kinase perturbation
0.48


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.16   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 85   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.16   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 85   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hematological measurement
1
1
1
85.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hematological measurement
1
85.1
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
Mov10 RISC complex RNA helicase like 1
720612
Mouse
MGI:1891384
83456
Rat
RGD:1304735
300141
Dog
Mov10 RISC complex RNA helicase like 1
VGNC:43328
474460
Horse
Mov10 RISC complex RNA helicase like 1
VGNC:20276
100056030
Species
Name
OMA
EggNOG
Inparanoid
Macaque
Mov10 RISC complex RNA helicase like 1
Mouse
Rat
Dog
Mov10 RISC complex RNA helicase like 1
Horse
Mov10 RISC complex RNA helicase like 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9BXT6-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (3)
Gene Silencing by RNA (R-HSA-211000)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene Silencing by RNA
Reactome
Gene expression (Transcription)
Reactome
PIWI-interacting RNA (piRNA) biogenesis
Name
Explore in Pharos
Explore in Source
Gene Silencing by RNA
Gene expression (Transcription)
PIWI-interacting RNA (piRNA) biogenesis
Gene Ontology Terms (14)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Traceable Author Statement (TAS)
UniProtKB
Traceable Author Statement (TAS)
UniProtKB
Traceable Author Statement (TAS)
UniProtKB
Protein-Protein Interactions (62)
1 – 10 of 62
TDRD9
Tbio
Family: Epigenetic
Novelty: 0.10913126
Score: 0.99
Data Source: STRINGDB
PIWIL4
Tbio
Novelty: 0.00105088
Score: 0.986
Data Source: STRINGDB
PIWIL2
Tbio
Novelty: 0.00907402
Score: 0.986
Data Source: STRINGDB
MAEL
Tbio
Novelty: 0.01925239
Score: 0.984
Data Source: STRINGDB
ASZ1
Tbio
Novelty: 0.0011137
Score: 0.983
Data Source: STRINGDB
TDRD1
Tbio
Family: Epigenetic
Novelty: 0.04645566
Score: 0.978
Data Source: STRINGDB
TDRD12
Tdark
Family: Epigenetic
Novelty: 0.2276017
Score: 0.969
Data Source: STRINGDB
PIWIL1
Tbio
Novelty: 0.00095911
Score: 0.962
Data Source: STRINGDB
HENMT1
Tdark
Family: Enzyme
Novelty: 0.17427834
Score: 0.96
Data Source: STRINGDB
FKBP6
Tbio
Family: Enzyme
Novelty: 0.02240256
Score: 0.96
Data Source: STRINGDB
Publication Statistics
PubMed Score  11.16

PubMed score by year
PubTator Score  5.87

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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