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Tchem
PHLPP1
PH domain leucine-rich repeat-containing protein phosphatase 1

Protein Summary
Description
Protein phosphatase involved in regulation of Akt and PKC signaling. Mediates dephosphorylation in the C-terminal domain hydrophobic motif of members of the AGC Ser/Thr protein kinase family; specifically acts on 'Ser-473' of AKT2 and AKT3, 'Ser-660' of PRKCB and 'Ser-657' of PRKCA (PubMed:15808505, PubMed:17386267, PubMed:18162466). Isoform 2 seems to have a major role in regulating Akt signaling in hippocampal neurons (By similarity). Akt regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of 'Ser-473' of Akt triggers apoptosis and suppression of tumor growth. Dephosphorylation of PRKCA and PRKCB leads to their destabilization and degradation (PubMed:18162466). Dephosphorylates STK4 on 'Thr-387' leading to STK4 activation and apoptosis (PubMed:20513427). Dephosphorylates RPS6KB1 and is involved in regulation of cap-dependent translation (Pu ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262719
  • ENSP00000262719
  • ENSG00000081913

Symbol
  • KIAA0606
  • PHLPP
  • PLEKHE1
  • SCOP
  • SCOP
  • PHLPP
  • PPM3A
  • PLEKHE1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
pathway
0.93
kinase perturbation
0.88
disease perturbation
0.87
transcription factor binding site profile
0.86
virus perturbation
0.72


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 149.79   (req: < 5)
Gene RIFs: 54   (req: <= 3)
Antibodies: 157   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 149.79   (req: >= 5)
Gene RIFs: 54   (req: > 3)
Antibodies: 157   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 3
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet crit
1
1
1
27
body mass index
1
1
1
13.9
1
1
0
1.4
7.7
neoplasm of mature B-cells
1
1
0
1.3
6.8
lymphocyte count
1
1
1
3.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet crit
1
27
body mass index
1
13.9
0
1.4
7.7
neoplasm of mature B-cells
0
1.3
6.8
lymphocyte count
1
3.1
Pathways (36)
Intracellular signaling by second messengers (R-HSA-9006925)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Intracellular signaling by second messengers
Reactome
Negative regulation of the PI3K/AKT network
Reactome
PIP3 activates AKT signaling
Reactome
Signal Transduction
Name
Explore in Pharos
Explore in Source
Intracellular signaling by second messengers
Negative regulation of the PI3K/AKT network
PIP3 activates AKT signaling
Signal Transduction
Gene Ontology Terms (16)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (124)
1 – 10 of 124
HAVCR2
Tbio
Novelty: 0.00155885
p_int: 0.999999091
p_ni: 9.09e-7
Data Source: BioPlex
USP46
Tbio
Family: Enzyme
Novelty: 0.04594593
p_int: 0.999989802
p_ni: 0.000010186
p_wrong: 1.2e-8
Score: 0.835
Data Source: BioPlex,STRINGDB
SLC9A3R2
Tbio
Family: Transporter
Novelty: 0.01401705
p_int: 0.996554616
p_ni: 0.003443909
p_wrong: 0.000001475
Score: 0.337
Data Source: BioPlex,STRINGDB
EFNB2
Tbio
Novelty: 0.00255095
p_int: 0.994782943
p_ni: 0.005216017
p_wrong: 0.00000104
Score: 0.15
Data Source: BioPlex,STRINGDB
USP1
Tchem
Family: Enzyme
Novelty: 0.0092606
p_int: 0.943165926
p_ni: 0.056831754
p_wrong: 0.00000232
Score: 0.606
Data Source: BioPlex,STRINGDB
RFPL2
Tdark
Novelty: 1.87914964
p_int: 0.911673559
p_ni: 0.076313421
p_wrong: 0.01201302
Score: 0.227
Data Source: BioPlex,STRINGDB
SKP2
Tbio
Family: Enzyme
Novelty: 0.00182658
p_int: 0.883000579
p_ni: 0.087267034
p_wrong: 0.029732387
Score: 0.272
Data Source: BioPlex,STRINGDB
AKT1
Tchem
Family: Kinase
Novelty: 0.00003185
Score: 0.991
Data Source: Reactome,STRINGDB
AKT3
Tchem
Family: Kinase
Novelty: 0.00308931
Score: 0.985
Data Source: STRINGDB
AKT2
Tchem
Family: Kinase
Novelty: 0.00167027
Score: 0.976
Data Source: STRINGDB
Publication Statistics
PubMed Score  149.79

PubMed score by year
PubTator Score  109.22

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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