Protein Summary
Essential for the control of the cell cycle at the G1/S (start) transition. The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK2, whose activity is required for cell cycle G1/S transition. This protein accumulates at the G1-S phase boundary and is degraded as cells progress through S phase. Overexpression of this gene has been observed in many tumors, which results in chromosome instability, and thus may contribute to tumorigenesis. This protein was found to associate with, and be involved in, the phosphorylation of NPAT protein (nuclear protein mapped to the ATM locus), which participates in cell ...more
- ENST00000262643
- ENSP00000262643
- ENSG00000105173
- ENST00000444983
- ENSP00000410179
- CCNE
- CCNE
- pCCNE1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
chemical | 1 | ||
virus perturbation | 0.94 | ||
PubMedID | 0.92 | ||
biological term | 0.84 | ||
kinase perturbation | 0.84 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 393.4 (req: < 5)
Gene RIFs: 225 (req: <= 3)
Antibodies: 1089 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 393.4 (req: >= 5)
Gene RIFs: 225 (req: > 3)
Antibodies: 1089 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 22
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 1
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (1)
Protein-Protein Interactions (347)
CDK2
Family: Kinase
Novelty: 0.00032118
p_int: 0.999999979
p_ni: 4e-9
p_wrong: 1.7e-8
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
CDKN1A
Family: Enzyme
Novelty: 0.00033009
p_int: 0.999999949
p_ni: 3e-9
p_wrong: 4.8e-8
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
CDK3
Family: Kinase
Novelty: 0.03380289
p_int: 0.999993492
p_ni: 0.000006508
Score: 0.962
Data Source: BioPlex,STRINGDB
PCNA
Novelty: 0.03909539
p_int: 0.998873777
p_ni: 0.000097202
p_wrong: 0.001029021
Score: 0.991
Data Source: BioPlex,STRINGDB
CKS2
Family: Enzyme
Novelty: 0.02482411
p_int: 0.998789887
p_ni: 0.000035525
p_wrong: 0.001174587
Score: 0.946
Data Source: BioPlex,STRINGDB
CKS1B
Family: Enzyme
Novelty: 0.00766779
p_int: 0.998725846
p_ni: 0.00003286
p_wrong: 0.001241294
Score: 0.991
Data Source: BioPlex,Reactome,STRINGDB
CDK7
Family: Kinase
Novelty: 0.00322814
p_int: 0.968478594
p_ni: 0.031507904
p_wrong: 0.000013502
Score: 0.963
Data Source: BioPlex,STRINGDB
CDK5
Family: Kinase
Novelty: 0.00071394
p_int: 0.844911256
p_ni: 0.154957535
p_wrong: 0.000131209
Score: 0.854
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets (4)
Upstream (2)
Downstream (2)
1 – 2 of 2
CDK6
CDK4
Pathways (88)
Reactome (37)
KEGG (17)
PathwayCommons (17)
WikiPathways (17)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Association of TriC/CCT with target proteins during biosynthesis | ||||
Reactome | CDK-mediated phosphorylation and removal of Cdc6 | ||||
Reactome | Cell Cycle | ||||
Reactome | Cell Cycle Checkpoints | ||||
Reactome | Cell Cycle, Mitotic | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Association of TriC/CCT with target proteins during biosynthesis | ||||
CDK-mediated phosphorylation and removal of Cdc6 | ||||
Cell Cycle | ||||
Cell Cycle Checkpoints | ||||
Cell Cycle, Mitotic | ||||
Viral Interactions (0)
Gene Ontology Terms (29)
Functions (5)
Components (7)
Processes (17)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Traceable Author Statement (TAS) | Reactome | |||
Non-traceable Author Statement (NAS) | UniProtKB | |||
Non-traceable Author Statement (NAS) | UniProtKB | |||
Disease Associations ()
GWAS Traits (14)
Items per page:
1 – 5 of 14
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
body mass index | 4 | 2 | 4 | 77.5 | |||||
mathematical ability | 3 | 2 | 3 | 39.4 | |||||
calcium measurement | 1 | 1 | 1 | 33.1 | |||||
body height | 1 | 1 | 1 | 13 | |||||
visceral adipose tissue measurement | 1 | 1 | 1 | 12.2 | |||||
Items per page:
1 – 5 of 14
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
body mass index | 4 | 77.5 | |||||
mathematical ability | 3 | 39.4 | |||||
calcium measurement | 1 | 33.1 | |||||
body height | 1 | 13 | |||||
visceral adipose tissue measurement | 1 | 12.2 | |||||
Find similar targets by:
IDG Resources
Orthologs (14)
1 – 5 of 14
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | cyclin E1 | VGNC:2368 | 455914 | |||||
Macaque | cyclin E1 | 700589 | ||||||
Mouse | MGI:88316 | 12447 | ||||||
Rat | RGD:2294 | 25729 | ||||||
Dog | cyclin E1 | VGNC:38898 | 484610 | |||||
Publication Statistics
PubMed Score 393.40
PubMed score by year
PubTator Score 208.65
PubTator score by year
Related Publications
Text Mined References (311)
GeneRif Annotations (225)
Items per page:
0 of 0
PMID | Year | Title |
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