Tchem CCNE1 G1/S-specific cyclin-E1

Protein Summary

Description

Essential for the control of the cell cycle at the G1/S (start) transition. The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK2, whose activity is required for cell cycle G1/S transition. This protein accumulates at the G1-S phase boundary and is degraded as cells progress through S phase. Overexpression of this gene has been observed in many tumors, which results in chromosome instability, and thus may contribute to tumorigenesis. This protein was found to associate with, and be involved in, the phosphorylation of NPAT protein (nuclear protein mapped to the ATM locus), which participates in cell-cycle regulated histone gene expression and plays a critical role in promoting cell-cycle progression in the absence of pRB. [provided by RefSeq, Apr 2016]

Uniprot Accession IDs

• P24864
• A8K684
• Q14091
• Q8NFG1
• Q92501
• Q9UD21

Gene Name

• CCNE1

Ensembl ID

• ENST00000262643
• ENSP00000262643
• ENSG00000105173
• ENST00000444983
• ENSP00000410179

Symbol

• CCNE
• CCNE
• pCCNE1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
chemical	1
virus perturbation	0.94
PubMedID	0.92
biological term	0.84
kinase perturbation	0.84

Protein Classes

PANTHER Classes

Protein / Enzyme Modulator / Kinase Modulator / Kinase Activator / G1/s-specific Cyclin-e1

DTO Classes

Protein / Enzyme Modulator / Kinase Modulator / Kinase Activator / G1/s-specific Cyclin-e1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 393.4   (req: < 5)

Gene RIFs: 225   (req: <= 3)

Antibodies: 1089   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 393.4   (req: >= 5)

Gene RIFs: 225   (req: > 3)

Antibodies: 1089   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 22

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

Find Targets by Sequence

Show Full Sequence

ProtVista Viewer

Expression Data (0 Tissues)

tutorial

No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

Go To Tool

GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

Go To Tool

GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

Go To Tool

ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

Go To Tool

Approved Drugs (0)

No approved drugs found

Active Ligands (1)

Explore Active Ligands

1 – 1 of 1

AZD5438

CCNE1Tchem

pIC50 : 8.22

Protein-Protein Interactions (347)

Explore Interacting Targets

1 – 10 of 347

• See Interactions on String-DB

CDK2

Tchem

Family:  Kinase

Novelty:  0.00032118

p_int:  0.999999979

p_ni:  4e-9

p_wrong:  1.7e-8

Score:  0.999

Data Source:  BioPlex,Reactome,STRINGDB

CDKN1A

Tchem

Family:  Enzyme

Novelty:  0.00033009

p_int:  0.999999949

p_ni:  3e-9

p_wrong:  4.8e-8

Score:  0.999

Data Source:  BioPlex,Reactome,STRINGDB

CDK3

Tchem

Family:  Kinase

Novelty:  0.03380289

p_int:  0.999993492

p_ni:  0.000006508

Score:  0.962

Data Source:  BioPlex,STRINGDB

PCNA

Tchem

Novelty:  0.03909539

p_int:  0.998873777

p_ni:  0.000097202

p_wrong:  0.001029021

Score:  0.991

Data Source:  BioPlex,STRINGDB

CKS2

Tbio

Family:  Enzyme

Novelty:  0.02482411

p_int:  0.998789887

p_ni:  0.000035525

p_wrong:  0.001174587

Score:  0.946

Data Source:  BioPlex,STRINGDB

CKS1B

Tbio

Family:  Enzyme

Novelty:  0.00766779

p_int:  0.998725846

p_ni:  0.00003286

p_wrong:  0.001241294

Score:  0.991

Data Source:  BioPlex,Reactome,STRINGDB

CDK7

Tchem

Family:  Kinase

Novelty:  0.00322814

p_int:  0.968478594

p_ni:  0.031507904

p_wrong:  0.000013502

Score:  0.963

Data Source:  BioPlex,STRINGDB

CDK5

Tchem

Family:  Kinase

Novelty:  0.00071394

p_int:  0.844911256

p_ni:  0.154957535

p_wrong:  0.000131209

Score:  0.854

Data Source:  BioPlex,STRINGDB

CDK4

Tclin

Family:  Kinase

Novelty:  0.00036742

Score:  0.999

Data Source:  STRINGDB

CDKN1B

Tbio

Family:  Enzyme

Novelty:  0.00069449

Score:  0.999

Data Source:  Reactome,STRINGDB

Nearest Tclin Targets (4)

Explore Nearest Tclin Targets

Upstream (2)

Downstream (2)

1 – 2 of 2

CDK6

Tclin

Family:  Kinase

KEGG Distance:  1

Common Pathways:  12

1: PI3K-Akt signaling pathway

2: Cushing syndrome

3: Cell cycle

4: Small cell lung cancer

more:  8 more common pathways

CDK4

Tclin

Family:  Kinase

KEGG Distance:  1

Common Pathways:  12

1: PI3K-Akt signaling pathway

2: Cushing syndrome

3: Cell cycle

4: Small cell lung cancer

more:  8 more common pathways

Pathways (88)

Reactome (37)

KEGG (17)

PathwayCommons (17)

WikiPathways (17)

Association of TriC/CCT with target proteins during biosynthesis (R-HSA-390471)

Click on a row in the table to change the structure displayed.

Find Similar Targets

Items per page:

5

1 – 5 of 37

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Association of TriC/CCT with target proteins during biosynthesis	39 targets	R-HSA-390471
Reactome	CDK-mediated phosphorylation and removal of Cdc6	73 targets	R-HSA-69017
Reactome	Cell Cycle	597 targets	R-HSA-1640170
Reactome	Cell Cycle Checkpoints	272 targets	R-HSA-69620
Reactome	Cell Cycle, Mitotic	495 targets	R-HSA-69278

Name	Explore in Pharos	Explore in Source
Association of TriC/CCT with target proteins during biosynthesis	39 targets	R-HSA-390471
CDK-mediated phosphorylation and removal of Cdc6	73 targets	R-HSA-69017
Cell Cycle	597 targets	R-HSA-1640170
Cell Cycle Checkpoints	272 targets	R-HSA-69620
Cell Cycle, Mitotic	495 targets	R-HSA-69278

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (29)

Functions (5)

Components (7)

Processes (17)

Find Similar Targets

Items per page:

10

1 – 5 of 5

GO Term	Evidence	Assigned by
cyclin-dependent protein serine/threonine kinase regulator activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
protein kinase binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
cyclin-dependent protein serine/threonine kinase activity	Traceable Author Statement (TAS)	Reactome
androgen receptor binding	Non-traceable Author Statement (NAS)	UniProtKB
transcription coactivator activity	Non-traceable Author Statement (NAS)	UniProtKB

Disease Associations ()

No disease associations found

GWAS Traits (14)

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 14

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
body mass index	EFO_0004340	4	2	4		77.5
mathematical ability	EFO_0004875	3	2	3		39.4
calcium measurement	EFO_0004838	1	1	1		33.1
body height	EFO_0004339	1	1	1		13
visceral adipose tissue measurement	EFO_0004765	1	1	1		12.2

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 14

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
body mass index	EFO_0004340	4		77.5
mathematical ability	EFO_0004875	3		39.4
calcium measurement	EFO_0004838	1		33.1
body height	EFO_0004339	1		13
visceral adipose tissue measurement	EFO_0004765	1		12.2

Reset Zoom  Beta Count   Odds Ratio

Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Alternative splicing
Cell cycle
Cell division
Complete proteome
Cyclin
Nucleus
Phosphoprotein
Reference proteome
Ubl conjugation

GWAS Trait Find Similar Targets

No Header	No Header
bladder carcinoma
body height
body mass index
breast carcinoma
calcium measurement
cognitive function measurement
diastolic blood pressure
Diuretic use measurement
gait measurement
mathematical ability

MGI Phenotype Find Similar Targets

No Header	No Header
cellular phenotype
digestive/alimentary phenotype
endocrine/exocrine gland phenotype
hematopoietic system phenotype
immune system phenotype
integument phenotype
skeleton phenotype

IDG Resources

No IDG generated resources found

Orthologs (14)

1 – 5 of 14

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	cyclin E1	VGNC:2368	455914
Macaque	cyclin E1		700589
Mouse	cyclin E1	MGI:88316	12447
Rat	cyclin E1	RGD:2294	25729
Dog	cyclin E1	VGNC:38898	484610

Species	Name	OMA	EggNOG	Inparanoid
Chimp	cyclin E1
Macaque	cyclin E1
Mouse	cyclin E1
Rat	cyclin E1
Dog	cyclin E1

Publication Statistics

PubMed Score 393.40

PubMed score by year

Reset Zoom

PubTator Score 208.65

PubTator score by year

Reset Zoom

Related Publications

Text Mined References (311)

GeneRif Annotations (225)

Items per page:

10

0 of 0

PMID	Year	Title