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Tbio
SLC9A3R1
Na(+)/H(+) exchange regulatory cofactor NHE-RF1

Protein Summary
Description
Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. Necessary for recycling of internalized ADRB2. Was first known to play a role in the regulation of the activity and subcellular location of SLC9A3. Necessary for cAMP-mediated phosphorylation and inhibition of SLC9A3. May enhance Wnt signaling. May participate in HTR4 targeting to microvilli (By similarity). Involved in the regulation of phosphate reabsorption in the renal proximal tubules. Involved in sperm capacitation. May participate in the regulation of the chloride and bicarbonate homeostasis in spermatozoa. This gene encodes a sodium/hydrogen exchanger regulatory cofactor. The protein interacts with and regulates various proteins including the cystic fibrosis transmembrane conductance regulator and G-protein coupled receptors such as the beta2-adrenergic receptor and the parathyr ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262613
  • ENSP00000262613
  • ENSG00000109062
  • ENST00000413388
  • ENSP00000464982

Symbol
  • NHERF
  • NHERF1
  • EBP50
  • NHERF
  • NHERF1
  • NHERF-1
  • NPHLOP2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.98
disease perturbation
0.96
transcription factor perturbation
0.94
cellular component
0.86
transcription factor binding site profile
0.86


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 331.75   (req: < 5)
Gene RIFs: 145   (req: <= 3)
Antibodies: 316   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 331.75   (req: >= 5)
Gene RIFs: 145   (req: > 3)
Antibodies: 316   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 48
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte percentage of leukocytes
2
2
2
62.1
monocyte count
2
2
2
55.6
leukocyte count
1
2
2
51.3
red blood cell distribution width
1
1
1
50.8
neutrophil count
1
1
1
30.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte percentage of leukocytes
2
62.1
monocyte count
2
55.6
leukocyte count
2
51.3
red blood cell distribution width
1
50.8
neutrophil count
1
30.4
Protein Data Bank (19)
1 – 5 of 19
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (6)
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
KEGG
Parathyroid hormone synthesis, secretion and action
KEGG
Tight junction
KEGG
Human papillomavirus infection
Name
Explore in Pharos
Explore in Source
Parathyroid hormone synthesis, secretion and action
Tight junction
Human papillomavirus infection
Gene Ontology Terms (65)
Items per page:
10
1 – 10 of 13
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (153)
1 – 10 of 153
TCHHL1
Tdark
Novelty: 0.21799821
p_int: 0.86807732
p_ni: 0.131921079
p_wrong: 0.000001602
Data Source: BioPlex
SNRNP27
Tbio
Novelty: 0.0175187
p_int: 0.852855532
p_ni: 0.147144466
p_wrong: 3e-9
Score: 0.19
Data Source: BioPlex,STRINGDB
EZR
Tbio
Novelty: 0.00115353
Score: 0.998
Data Source: STRINGDB
MSN
Tbio
Novelty: 0.00178275
Score: 0.995
Data Source: STRINGDB
PTEN
Tchem
Family: Enzyme
Novelty: 0.00013818
Score: 0.991
Data Source: STRINGDB
CFTR
Tclin
Family: IC
Novelty: 0.00012639
Score: 0.984
Data Source: STRINGDB
PDGFRB
Tclin
Family: Kinase
Novelty: 0.00074896
Score: 0.977
Data Source: STRINGDB
RDX
Tbio
Novelty: 0.00236103
Score: 0.974
Data Source: STRINGDB
ADRB2
Tclin
Family: GPCR
Novelty: 0.00041821
Score: 0.956
Data Source: STRINGDB
GNAQ
Tbio
Novelty: 0.0008997
Score: 0.934
Data Source: STRINGDB
Publication Statistics
PubMed Score  331.75

PubMed score by year
PubTator Score  216.4

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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