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Tbio
RPL8
60S ribosomal protein L8

Protein Summary
Description
Component of the large ribosomal subunit. Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L2P family of ribosomal proteins. It is located in the cytoplasm. In rat, the protein associates with the 5.8S rRNA, very likely participates in the binding of aminoacyl-tRNA, and is a constituent of the elongation factor 2-binding site at the ribosomal subunit interface. Alternatively spliced transcript variants encoding the same protein exist. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262584
  • ENSP00000262584
  • ENSG00000161016
  • ENST00000394920
  • ENSP00000378378
  • ENST00000528957
  • ENSP00000433464

Symbol
  • L8
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
interacting protein
1
kinase perturbation
0.99
protein domain
0.99
microRNA
0.95


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 90.04   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 279   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 90.04   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 279   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ribosomal protein L8
VGNC:803
464473
Macaque
ribosomal protein L8
708535
Mouse
MGI:1350927
26961
Dog
ribosomal protein L8
VGNC:45720
475130
Horse
ribosomal protein L8 [Source:HGNC Symbol;Acc:HGNC:10368]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ribosomal protein L8
Macaque
ribosomal protein L8
Mouse
Dog
ribosomal protein L8
Horse
ribosomal protein L8 [Source:HGNC Symbol;Acc:HGNC:10368]
Protein Structure (10 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P62917-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 10
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (35)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 32
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Cap-dependent Translation Initiation
Reactome
Developmental Biology
Reactome
Disease
Reactome
Eukaryotic Translation Elongation
Name
Explore in Pharos
Explore in Source
Axon guidance
Cap-dependent Translation Initiation
Developmental Biology
Disease
Eukaryotic Translation Elongation
Gene Ontology Terms (15)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (600)
1 – 10 of 600
PUM3
Tbio
Novelty: 0.02344206
p_int: 0.998054454
p_ni: 0.001945546
Score: 0.665
Data Source: BioPlex,STRINGDB
RPL37A
Tbio
Novelty: 0.03475061
p_int: 0.997999187
p_ni: 0.002000813
Score: 0.999
Data Source: BioPlex,STRINGDB
H1FOO
Tbio
Novelty: 0.02189067
p_int: 0.993111572
p_ni: 0.006888428
Score: 0.186
Data Source: BioPlex,STRINGDB
ZC3HAV1
Tbio
Novelty: 0.01357759
p_int: 0.987052934
p_ni: 0.012947066
Score: 0.549
Data Source: BioPlex,STRINGDB
RBM34
Tdark
Novelty: 0.58131282
p_int: 0.976304685
p_ni: 0.023695315
Score: 0.566
Data Source: BioPlex,STRINGDB
RRP8
Tbio
Family: Enzyme
Novelty: 0.04922797
p_int: 0.975103156
p_ni: 0.024896844
Score: 0.555
Data Source: BioPlex,STRINGDB
RPL7L1
Tdark
Novelty: 0.78428937
p_int: 0.974419301
p_ni: 0.025580699
Score: 0.939
Data Source: BioPlex,STRINGDB
RRS1
Tbio
Novelty: 0.01643671
p_int: 0.968195872
p_ni: 0.031804128
Score: 0.759
Data Source: BioPlex,STRINGDB
GLYR1
Tbio
Family: Epigenetic
Novelty: 0.036121
p_int: 0.964211397
p_ni: 0.035788603
Score: 0.561
Data Source: BioPlex,STRINGDB
RPL26L1
Tdark
Novelty: 0.75408617
p_int: 0.950966328
p_ni: 0.049033672
Score: 0.999
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  90.04

PubMed score by year
PubTator Score  12.18

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer