You are using an outdated browser. Please upgrade your browser to improve your experience.

Tchem
SPTLC1
Serine palmitoyltransferase 1

Protein Summary
Description
Serine palmitoyltransferase (SPT). The heterodimer formed with SPTLC2 or SPTLC3 constitutes the catalytic core. The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC3-SPTSSA isozyme uses both C14-CoA and C16-CoA as substrates, with a slight preference for C14-CoA. The SPTLC1-SPTLC2-SPTSSB complex shows a strong preference for C18-CoA substrate, while the SPTLC1-SPTLC3-SPTSSB isozyme displays an ability to use a broader range of acyl-CoAs, without apparent preference. This gene encodes a member of the class-II pyridoxal-phosphate-dependent aminotransferase family. The encoded protein is the long chain base subunit 1 of serine palmitoyltransferase. Serine palmitoyltransferase converts L-serine and palmitoyl-CoA to 3-oxosphinganine with pyridoxal 5'-phosphate and is the key enzyme in sphingolipid biosynthesis. Mutations in this gene were ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262554
  • ENSP00000262554
  • ENSG00000090054
  • ENST00000337841
  • ENSP00000337635

Symbol
  • LCB1
  • HSN1
  • LBC1
  • LCB1
  • SPT1
  • SPTI
  • HSAN1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.95
interacting protein
0.9
transcription factor perturbation
0.84
histone modification site profile
0.8
transcription factor
0.72


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 158.15   (req: < 5)
Gene RIFs: 25   (req: <= 3)
Antibodies: 354   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 158.15   (req: >= 5)
Gene RIFs: 25   (req: > 3)
Antibodies: 354   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
serine palmitoyltransferase long chain base subunit 1
VGNC:10108
464590
Macaque
serine palmitoyltransferase long chain base subunit 1
705324
Mouse
MGI:1099431
268656
Rat
RGD:1307140
361213
Dog
serine palmitoyltransferase long chain base subunit 1
VGNC:46779
484192
Species
Name
OMA
EggNOG
Inparanoid
Chimp
serine palmitoyltransferase long chain base subunit 1
Macaque
serine palmitoyltransferase long chain base subunit 1
Mouse
Rat
Dog
serine palmitoyltransferase long chain base subunit 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-O15269-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (11)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Sphingolipid de novo biosynthesis
Reactome
Sphingolipid metabolism
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of lipids
Sphingolipid de novo biosynthesis
Sphingolipid metabolism
Protein-Protein Interactions (114)
1 – 10 of 114
SPTSSA
Tbio
Family: Enzyme
Novelty: 0.13352078
Score: 0.995
Data Source: Reactome,STRINGDB
SPTSSB
Tdark
Family: Enzyme
Novelty: 0.05967882
Score: 0.993
Data Source: Reactome,STRINGDB
SPTLC2
Tchem
Family: Enzyme
Novelty: 0.01236952
Score: 0.991
Data Source: Reactome,STRINGDB
SPTLC3
Tbio
Family: Enzyme
Novelty: 0.03671571
Score: 0.99
Data Source: Reactome,STRINGDB
ORMDL3
Tbio
Novelty: 0.00958976
Score: 0.982
Data Source: STRINGDB
KDSR
Tbio
Family: Enzyme
Novelty: 0.0408411
Score: 0.979
Data Source: STRINGDB
ORMDL1
Tbio
Novelty: 0.1323746
Score: 0.92
Data Source: STRINGDB
GOLGA7
Tbio
Novelty: 0.17108842
Score: 0.902
Data Source: STRINGDB
ZDHHC9
Tbio
Family: Enzyme
Novelty: 0.04949094
Score: 0.9
Data Source: STRINGDB
ORMDL2
Tdark
Novelty: 0.37598406
Score: 0.876
Data Source: STRINGDB
Publication Statistics
PubMed Score  158.15

PubMed score by year
PubTator Score  97.41

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer