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Tbio
INVS
Inversin

Protein Summary
Description
Required for normal renal development and establishment of left-right axis. Probably acts as a molecular switch between different Wnt signaling pathways. Inhibits the canonical Wnt pathway by targeting cytoplasmic disheveled (DVL1) for degradation by the ubiquitin-proteasome. This suggests that it is required in renal development to oppose the repression of terminal differentiation of tubular epithelial cells by Wnt signaling. Involved in the organization of apical junctions in kidney cells together with NPHP1, NPHP4 and RPGRIP1L/NPHP8 (By similarity). Does not seem to be strictly required for ciliogenesis (By similarity). This gene encodes a protein containing multiple ankyrin domains and two IQ calmodulin-binding domains. The encoded protein may function in renal tubular development and function, and in left-right axis determination. This protein interacts with nephrocystin and infers a connection between primary cilia function and left-right axis determination. A similar protein in ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262456
  • ENSP00000262456
  • ENSG00000119509
  • ENST00000262457
  • ENSP00000262457
  • ENST00000374921
  • ENSP00000364056

Symbol
  • INV
  • NPHP2
  • INV
  • NPH2
  • NPHP2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.88
transcription factor binding site profile
0.85
virus perturbation
0.79
cellular component
0.77
disease perturbation
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 136.64   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 96   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 136.64   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 96   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Gene Ontology Terms (10)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (113)
1 – 10 of 113
EXT2
Tbio
Family: Enzyme
Novelty: 0.0028975
p_int: 0.999988048
p_ni: 3.18e-7
p_wrong: 0.000011635
Score: 0.359
Data Source: BioPlex,STRINGDB
NPHP1
Tbio
Novelty: 0.01476935
Score: 0.974
Data Source: STRINGDB
DVL1
Tchem
Novelty: 0.00460899
Score: 0.964
Data Source: STRINGDB
DVL2
Tbio
Novelty: 0.01142063
Score: 0.957
Data Source: STRINGDB
DVL3
Tbio
Novelty: 0.02234457
Score: 0.926
Data Source: STRINGDB
NPHP3
Tbio
Novelty: 0.02548956
Score: 0.914
Data Source: STRINGDB
RPGR
Tbio
Family: Enzyme
Novelty: 0.00353224
Score: 0.877
Data Source: STRINGDB
NEK8
Tbio
Family: Kinase
Novelty: 0.01781961
Score: 0.873
Data Source: STRINGDB
NPHP4
Tbio
Novelty: 0.03648525
Score: 0.853
Data Source: STRINGDB
NEK9
Tchem
Family: Kinase
Novelty: 0.03227459
Score: 0.83
Data Source: STRINGDB
Publication Statistics
PubMed Score  136.64

PubMed score by year
PubTator Score  329.44

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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