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Tbio
CRISPLD2
Cysteine-rich secretory protein LCCL domain-containing 2

Protein Summary
Description
Promotes matrix assembly.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262424
  • ENSP00000262424
  • ENSG00000103196
  • ENST00000564567
  • ENSP00000457655
  • ENST00000569090
  • ENSP00000454858

Symbol
  • CRISP11
  • LCRISP2
  • LGL1
  • CRISP11
  • LCRISP2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.97
gene perturbation
0.9
small molecule perturbation
0.8
PubMedID
0.65
tissue
0.64


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.66   (req: < 5)
Gene RIFs: 18   (req: <= 3)
Antibodies: 123   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.66   (req: >= 5)
Gene RIFs: 18   (req: > 3)
Antibodies: 123   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (20)
DNHD1
Tdark
Novelty:  0.96803718
Score:  0.657
Data Source:  STRINGDB
ANKRD13D
Tdark
Novelty:  2.14380936
Score:  0.625
Data Source:  STRINGDB
ARSB
Tbio
Family:  Enzyme
Novelty:  0.01044355
Score:  0.571
Data Source:  STRINGDB
SGCA
Tbio
Novelty:  0.00442268
Score:  0.485
Data Source:  STRINGDB
NHLH1
Tbio
Family:  TF
Novelty:  0.01828505
Score:  0.481
Data Source:  STRINGDB
PM20D2
Tdark
Family:  Enzyme
Novelty:  0.63491472
Score:  0.477
Data Source:  STRINGDB
FOXE1
Tbio
Family:  TF
Novelty:  0.00783938
Score:  0.476
Data Source:  STRINGDB
WFIKKN1
Tbio
Novelty:  0.09604321
Score:  0.476
Data Source:  STRINGDB
FOLR1
Tchem
Novelty:  0.00283538
Score:  0.453
Data Source:  STRINGDB
DDN
Tbio
Novelty:  0.03151889
Score:  0.452
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Immune System (R-HSA-168256)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Neutrophil degranulation
Name
Explore in Pharos
Explore in Source
Immune System
Innate Immune System
Neutrophil degranulation
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte count
4
2
4
83
reticulocyte measurement
2
1
2
72.5
BMI-adjusted waist circumference
1
2
2
33
1
1
0
1.1
17.8
body height
1
1
1
6.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte count
4
83
reticulocyte measurement
2
72.5
BMI-adjusted waist circumference
2
33
0
1.1
17.8
body height
1
6.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cysteine rich secretory protein LCCL domain containing 2
VGNC:8975
454288
Macaque
cysteine rich secretory protein LCCL domain containing 2
715516
Mouse
MGI:1926142
78892
Rat
RGD:620860
171547
Dog
cysteine rich secretory protein LCCL domain containing 2
VGNC:39618
489677
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cysteine rich secretory protein LCCL domain containing 2
Macaque
cysteine rich secretory protein LCCL domain containing 2
Mouse
Rat
Dog
cysteine rich secretory protein LCCL domain containing 2
Publication Statistics
PubMed Score 36.66
PubMed score by year
PubTator Score 255.02
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title