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Tbio
GLIS2
Zinc finger protein GLIS2

Protein Summary
Description
Can act either as a transcriptional repressor or as a transcriptional activator, depending on the cell context. Acts as a repressor of the Hedgehog signaling pathway (By similarity). Represses the Hedgehog-dependent expression of Wnt4 (By similarity). Necessary to maintain the differentiated epithelial phenotype in renal cells through the inhibition of SNAI1, which itself induces the epithelial-to-mesenchymal transition (By similarity). Represses transcriptional activation mediated by CTNNB1 in the Wnt signaling pathway. May act by recruiting the corepressors CTBP1 and HDAC3. May be involved in neuron differentiation (By similarity). This gene is a member of the GLI-similar zinc finger protein family and encodes a nuclear transcription factor with five C2H2-type zinc finger domains. The protein encoded by this gene is widely expressed at low levels in the neural tube and peripheral nervous system and likely promotes neuronal differentiation. It is abundantly expressed in the kidney and ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262366
  • ENSP00000262366
  • ENSG00000126603
  • ENST00000433375
  • ENSP00000395547
  • ENST00000612491
  • ENSP00000484027
  • ENSG00000274636
  • ENST00000633051
  • ENSP00000488242

Symbol
  • NKL
  • NKL
  • NPHP7
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.74
tissue sample
0.68
molecular function
0.67
cellular component
0.64
transcription factor perturbation
0.61


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 144.15   (req: < 5)
Gene RIFs: 16   (req: <= 3)
Antibodies: 114   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 144.15   (req: >= 5)
Gene RIFs: 16   (req: > 3)
Antibodies: 114   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
GLIS family zinc finger 2
VGNC:51213
467893
Macaque
GLIS family zinc finger 2
708454
Mouse
MGI:1932535
83396
Rat
RGD:1309177
302946
Dog
GLIS family zinc finger 2
VGNC:41262
490028
Species
Name
OMA
EggNOG
Inparanoid
Chimp
GLIS family zinc finger 2
Macaque
GLIS family zinc finger 2
Mouse
Rat
Dog
GLIS family zinc finger 2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9BZE0-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (19)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (82)
1 – 10 of 82
KLRK1
Tbio
Novelty: 0.0009209
Score: 0.79
Data Source: STRINGDB
CTBP1
Tbio
Novelty: 0.00243818
Score: 0.732
Data Source: STRINGDB
CBFA2T3
Tbio
Novelty: 0.01235845
Score: 0.687
Data Source: STRINGDB
INVS
Tbio
Novelty: 0.00834489
Score: 0.645
Data Source: STRINGDB
CTNNB1
Tchem
Novelty: 0.0000744
Score: 0.633
Data Source: STRINGDB
NEK8
Tbio
Family: Kinase
Novelty: 0.00709572
Score: 0.618
Data Source: STRINGDB
ADCY9
Tbio
Family: Enzyme
Novelty: 0.00744116
Score: 0.589
Data Source: STRINGDB
FGF18
Tbio
Novelty: 0.00802997
Score: 0.585
Data Source: STRINGDB
ARMC8
Tbio
Novelty: 0.06820746
Score: 0.572
Data Source: STRINGDB
KLRC1
Tbio
Novelty: 0.00312379
Score: 0.571
Data Source: STRINGDB
Publication Statistics
PubMed Score  144.15

PubMed score by year
PubTator Score  20.49

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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