Protein Summary
Component of the beta-catenin destruction complex required for regulating CTNNB1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling (PubMed:12192039, PubMed:27098453). Controls dorsoventral patterning via two opposing effects; down-regulates CTNNB1 to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway (PubMed:12192039). In Wnt signaling, probably facilitates the phosphorylation of CTNNB1 and APC by GSK3B (PubMed:12192039). Likely to function as a tumor suppressor. Enhances TGF-beta signaling by recruiting the RNF111 E3 ubiquitin ligase and promoting the degradation of inhibitory SMAD7 (PubMed:16601693). Also component of the AXIN1-HIPK2-TP53 complex which controls cell growth, apoptosis and development (PubMed:17210684). Facilitates the phosphorylation of TP53 by HIPK2 upon ultraviolet irradiation (PubMed:17210684). This gene encodes a cytoplasmic protein which contains ...more
- ENST00000262320
- ENSP00000262320
- ENSG00000103126
- ENST00000354866
- ENSP00000346935
- AXIN
- AXIN
- PPP1R49
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
biological process | 1 | ||
molecular function | 0.95 | ||
hub protein | 0.92 | ||
phosphatase | 0.9 | ||
protein domain | 0.85 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 467.96 (req: < 5)
Gene RIFs: 103 (req: <= 3)
Antibodies: 477 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 467.96 (req: >= 5)
Gene RIFs: 103 (req: > 3)
Antibodies: 477 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 32
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (344)
WDYHV1
Family: Enzyme
Novelty: 0.1844203
p_int: 0.774650241
p_ni: 0.000001701
p_wrong: 0.225348058
Score: 0.224
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets (2)
Upstream (1)
Downstream (1)
1 – 1 of 1
Pathways (87)
Reactome (36)
KEGG (12)
PathwayCommons (22)
WikiPathways (17)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | AMER1 mutants destabilize the destruction complex | ||||
Reactome | APC truncation mutants have impaired AXIN binding | ||||
Reactome | AXIN missense mutants destabilize the destruction complex | ||||
Reactome | AXIN mutants destabilize the destruction complex, activating WNT signaling | ||||
Reactome | Beta-catenin phosphorylation cascade | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
AMER1 mutants destabilize the destruction complex | ||||
APC truncation mutants have impaired AXIN binding | ||||
AXIN missense mutants destabilize the destruction complex | ||||
AXIN mutants destabilize the destruction complex, activating WNT signaling | ||||
Beta-catenin phosphorylation cascade | ||||
Viral Interactions (0)
Gene Ontology Terms (40)
Functions (12)
Components (8)
Processes (20)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | IntAct | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Sequence or structural Similarity (ISS) | BHF-UCL | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Inferred from Sequence or structural Similarity (ISS) | BHF-UCL | |||
Disease Associations ()
GWAS Traits (31)
Items per page:
1 – 5 of 31
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
mean corpuscular hemoglobin concentration | 10 | 14 | 20 | 99.7 | |||||
heel bone mineral density | 3 | 8 | 15 | 98.9 | |||||
erythrocyte count | 6 | 8 | 12 | 98.1 | |||||
red blood cell distribution width | 7 | 5 | 9 | 97.4 | |||||
mean corpuscular hemoglobin | 3 | 5 | 5 | 97 | |||||
Items per page:
1 – 5 of 31
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
mean corpuscular hemoglobin concentration | 20 | 99.7 | |||||
heel bone mineral density | 15 | 98.9 | |||||
erythrocyte count | 12 | 98.1 | |||||
red blood cell distribution width | 9 | 97.4 | |||||
mean corpuscular hemoglobin | 5 | 97 | |||||
Find similar targets by:
IDG Resources
Orthologs (10)
1 – 5 of 10
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | axin 1 | VGNC:5679 | 453789 | |||||
Mouse | MGI:1096327 | 12005 | ||||||
Dog | axin 1 | VGNC:38324 | 490099 | |||||
Horse | axin 1 | VGNC:15716 | 100065116 | |||||
Cow | axin 1 | VGNC:26364 | 504357 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | axin 1 | |||||
Mouse | ||||||
Dog | axin 1 | |||||
Horse | axin 1 | |||||
Cow | axin 1 | |||||
Publication Statistics
PubMed Score 467.96
PubMed score by year
PubTator Score 290.74
PubTator score by year
Related Publications
Text Mined References (188)
GeneRif Annotations (103)
Items per page:
0 of 0
PMID | Year | Title |
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