Protein Classes
Protein Summary
Component of the beta-catenin destruction complex required for regulating CTNNB1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling (PubMed:12192039, PubMed:27098453). Controls dorsoventral patterning via two opposing effects; down-regulates CTNNB1 to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway (PubMed:12192039). In Wnt signaling, probably facilitates the phosphorylation of CTNNB1 and APC by GSK3B (PubMed:12192039). Likely to function as a tumor suppressor. Enhances TGF-beta signaling by recruiting the RNF111 E3 ubiquitin ligase and promoting the degradation of inhibitory SMAD7 (PubMed:16601693). Also component of the AXIN1-HIPK2-TP53 complex which controls cell growth, apoptosis and development (PubMed:17210684). Facilitates the phosphorylation of TP53 by HIPK2 upon ultraviolet irradiation (PubMed:17210684). This gene encodes a cytoplasmic protein which contains ...more
- ENST00000262320
- ENSP00000262320
- ENSG00000103126
- ENST00000354866
- ENSP00000346935
- AXIN
- AXIN
- PPP1R49
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological process | 1 | ||
molecular function | 0.95 | ||
hub protein | 0.92 | ||
phosphatase | 0.9 | ||
protein domain | 0.85 | ||
IDG Partner Tools
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 458.23 (req: < 5)
Gene RIFs: 103 (req: <= 3)
Antibodies: 477 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 458.23 (req: >= 5)
Gene RIFs: 103 (req: > 3)
Antibodies: 477 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 32
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
GWAS Traits (13)
Items per page:
1 – 5 of 13
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
heel bone mineral density | 3 | 5 | 12 | 97.9 | |||||
body mass index | 3 | 2 | 3 | 93.9 | |||||
bone density | 2 | 2 | 3 | 85.5 | |||||
mean corpuscular hemoglobin concentration | 1 | 2 | 2 | 73.8 | |||||
visceral adipose tissue measurement | 1 | 1 | 1 | 67.8 | |||||
Items per page:
1 – 5 of 13
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
heel bone mineral density | 12 | 97.9 | |||||
body mass index | 3 | 93.9 | |||||
bone density | 3 | 85.5 | |||||
mean corpuscular hemoglobin concentration | 2 | 73.8 | |||||
visceral adipose tissue measurement | 1 | 67.8 | |||||
Protein Data Bank (11)
1 – 5 of 11
PDB Structure Id | Ligand | Method | Resolution (Å) | M.W. (kDa) | Pub Year | Title |
|---|
PDB Structure Id | M.W. | Resolution | Pub Year |
|---|
Pathways (87)
Reactome (36)
KEGG (12)
PathwayCommons (22)
WikiPathways (17)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 36
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | AMER1 mutants destabilize the destruction complex | ||||
Reactome | APC truncation mutants have impaired AXIN binding | ||||
Reactome | AXIN missense mutants destabilize the destruction complex | ||||
Reactome | AXIN mutants destabilize the destruction complex, activating WNT signaling | ||||
Reactome | Beta-catenin phosphorylation cascade | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
AMER1 mutants destabilize the destruction complex | ||||
APC truncation mutants have impaired AXIN binding | ||||
AXIN missense mutants destabilize the destruction complex | ||||
AXIN mutants destabilize the destruction complex, activating WNT signaling | ||||
Beta-catenin phosphorylation cascade | ||||
Gene Ontology Terms (40)
Functions (12)
Components (8)
Processes (20)
Items per page:
10
1 – 10 of 12
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | IntAct | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Sequence or structural Similarity (ISS) | BHF-UCL | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Inferred from Sequence or structural Similarity (ISS) | BHF-UCL | |||
Protein-Protein Interactions (344)
1 – 10 of 344
GSK3A
Family: Kinase
Novelty: 0.00925708
p_int: 1
Score: 0.994
Data Source: BioPlex,STRINGDB
WDYHV1
Family: Enzyme
Novelty: 0.1844203
p_int: 0.774650241
p_ni: 0.000001701
p_wrong: 0.225348058
Score: 0.224
Data Source: BioPlex,STRINGDB
CTNNB1
Novelty: 0.0000744
Score: 0.999
Data Source: STRINGDB
GSK3B
Family: Kinase
Novelty: 0.00095115
Score: 0.999
Data Source: Reactome,STRINGDB
APC
Novelty: 0.00168376
Score: 0.999
Data Source: STRINGDB
LRP5
Novelty: 0.00089807
Score: 0.997
Data Source: STRINGDB
SIAH1
Family: Enzyme
Novelty: 0.00831224
Score: 0.997
Data Source: STRINGDB
LRP6
Novelty: 0.00305615
Score: 0.996
Data Source: Reactome,STRINGDB
DVL1
Novelty: 0.00356876
Score: 0.996
Data Source: Reactome,STRINGDB
TNKS
Family: Enzyme
Novelty: 0.00404545
Score: 0.992
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score 458.23
PubMed score by year
PubTator Score 290.74
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
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