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Tbio
AXIN1
Axin-1

Protein Summary
Description
Component of the beta-catenin destruction complex required for regulating CTNNB1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling (PubMed:12192039, PubMed:27098453). Controls dorsoventral patterning via two opposing effects; down-regulates CTNNB1 to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway (PubMed:12192039). In Wnt signaling, probably facilitates the phosphorylation of CTNNB1 and APC by GSK3B (PubMed:12192039). Likely to function as a tumor suppressor. Enhances TGF-beta signaling by recruiting the RNF111 E3 ubiquitin ligase and promoting the degradation of inhibitory SMAD7 (PubMed:16601693). Also component of the AXIN1-HIPK2-TP53 complex which controls cell growth, apoptosis and development (PubMed:17210684). Facilitates the phosphorylation of TP53 by HIPK2 upon ultraviolet irradiation (PubMed:17210684). This gene encodes a cytoplasmic protein which contains ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262320
  • ENSP00000262320
  • ENSG00000103126
  • ENST00000354866
  • ENSP00000346935

Symbol
  • AXIN
  • AXIN
  • PPP1R49
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
molecular function
0.95
hub protein
0.92
phosphatase
0.9
protein domain
0.85


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 458.23   (req: < 5)
Gene RIFs: 103   (req: <= 3)
Antibodies: 477   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 458.23   (req: >= 5)
Gene RIFs: 103   (req: > 3)
Antibodies: 477   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 32
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
3
5
12
97.9
body mass index
3
2
3
93.9
bone density
2
2
3
85.5
mean corpuscular hemoglobin concentration
1
2
2
73.8
visceral adipose tissue measurement
1
1
1
67.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
12
97.9
body mass index
3
93.9
bone density
3
85.5
mean corpuscular hemoglobin concentration
2
73.8
visceral adipose tissue measurement
1
67.8
Protein Data Bank (11)
1 – 5 of 11
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (87)
AMER1 mutants destabilize the destruction complex (R-HSA-4839748)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 36
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
AMER1 mutants destabilize the destruction complex
Reactome
APC truncation mutants have impaired AXIN binding
Reactome
AXIN missense mutants destabilize the destruction complex
Reactome
AXIN mutants destabilize the destruction complex, activating WNT signaling
Reactome
Beta-catenin phosphorylation cascade
Name
Explore in Pharos
Explore in Source
AMER1 mutants destabilize the destruction complex
APC truncation mutants have impaired AXIN binding
AXIN missense mutants destabilize the destruction complex
AXIN mutants destabilize the destruction complex, activating WNT signaling
Beta-catenin phosphorylation cascade
Gene Ontology Terms (40)
Items per page:
10
1 – 10 of 12
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Protein-Protein Interactions (344)
1 – 10 of 344
GSK3A
Tclin
Family: Kinase
Novelty: 0.00925708
p_int: 1
Score: 0.994
Data Source: BioPlex,STRINGDB
WDYHV1
Tbio
Family: Enzyme
Novelty: 0.1844203
p_int: 0.774650241
p_ni: 0.000001701
p_wrong: 0.225348058
Score: 0.224
Data Source: BioPlex,STRINGDB
CTNNB1
Tchem
Novelty: 0.0000744
Score: 0.999
Data Source: STRINGDB
GSK3B
Tclin
Family: Kinase
Novelty: 0.00095115
Score: 0.999
Data Source: Reactome,STRINGDB
APC
Tbio
Novelty: 0.00168376
Score: 0.999
Data Source: STRINGDB
LRP5
Tbio
Novelty: 0.00089807
Score: 0.997
Data Source: STRINGDB
SIAH1
Tbio
Family: Enzyme
Novelty: 0.00831224
Score: 0.997
Data Source: STRINGDB
LRP6
Tbio
Novelty: 0.00305615
Score: 0.996
Data Source: Reactome,STRINGDB
DVL1
Tchem
Novelty: 0.00356876
Score: 0.996
Data Source: Reactome,STRINGDB
TNKS
Tchem
Family: Enzyme
Novelty: 0.00404545
Score: 0.992
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  458.23

PubMed score by year
PubTator Score  290.74

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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