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Tclin
PSMB1
Proteasome subunit beta type-1

Protein Summary
Description
Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262193
  • ENSP00000262193
  • ENSG00000008018

Symbol
  • PSC5
  • HC5
  • PSC5
  • PMSB1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
1
biological process
0.98
co-expressed gene
0.96
disease perturbation
0.95
histone modification site profile
0.83


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.66   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 217   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.66   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 217   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 27
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2
Approved Drugs (2)
1 – 2 of 2
bortezomib
chemical structure image
ixazomib
chemical structure image
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
proteasome subunit beta 1
VGNC:3675
473258
Macaque
proteasome subunit beta 1
696133
Mouse
MGI:104884
19170
Rat
RGD:621092
94198
Dog
proteasome subunit beta 1
VGNC:54344
475040
Species
Name
OMA
EggNOG
Inparanoid
Chimp
proteasome subunit beta 1
Macaque
proteasome subunit beta 1
Mouse
Rat
Dog
proteasome subunit beta 1
Protein Structure (56 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P20618-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 56
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (170)
ABC transporter disorders (R-HSA-5619084)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 149
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ABC transporter disorders
Reactome
ABC-family proteins mediated transport
Reactome
APC/C-mediated degradation of cell cycle proteins
Reactome
APC/C:Cdc20 mediated degradation of Securin
Reactome
APC/C:Cdc20 mediated degradation of mitotic proteins
Name
Explore in Pharos
Explore in Source
ABC transporter disorders
ABC-family proteins mediated transport
APC/C-mediated degradation of cell cycle proteins
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdc20 mediated degradation of mitotic proteins
Gene Ontology Terms (20)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (372)
1 – 10 of 372
PSMA8
Tdark
Family: Enzyme
Novelty: 0.83041547
p_int: 0.999999999
p_ni: 1e-9
Score: 0.999
Data Source: BioPlex,STRINGDB
PSME4
Tbio
Novelty: 0.01206213
p_int: 0.999999829
p_ni: 1.71e-7
Score: 0.993
Data Source: BioPlex,STRINGDB
PSMB4
Tbio
Family: Enzyme
Novelty: 0.0376233
p_int: 0.999999682
p_ni: 3.18e-7
Score: 0.999
Data Source: BioPlex,STRINGDB
PSMB7
Tbio
Family: Enzyme
Novelty: 0.06547657
p_int: 0.999999212
p_ni: 7.88e-7
Score: 0.999
Data Source: BioPlex,STRINGDB
PSMB2
Tclin
Family: Enzyme
Novelty: 0.06714761
p_int: 0.999997177
p_ni: 0.000002823
Score: 0.999
Data Source: BioPlex,STRINGDB
POMP
Tbio
Novelty: 0.01885028
p_int: 0.999995261
p_ni: 0.000004739
Score: 0.997
Data Source: BioPlex,STRINGDB
PSME2
Tbio
Novelty: 0.02624268
p_int: 0.999990031
p_ni: 0.000009969
Score: 0.987
Data Source: BioPlex,STRINGDB
PSMG2
Tbio
Novelty: 0.11082503
p_int: 0.999976615
p_ni: 0.000023385
Score: 0.981
Data Source: BioPlex,STRINGDB
PSMF1
Tbio
Novelty: 0.0364376
p_int: 0.999969406
p_ni: 0.000030594
Score: 0.983
Data Source: BioPlex,STRINGDB
PSMB3
Tbio
Family: Enzyme
Novelty: 0.12791198
p_int: 0.999967331
p_ni: 0.000032669
Score: 0.999
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  33.66

PubMed score by year
PubTator Score  15.22

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer