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Tbio
SMAD7
Mothers against decapentaplegic homolog 7

Protein Summary
Description
Antagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor superfamily members; has been shown to inhibit TGF-beta (Transforming growth factor) and activin signaling by associating with their receptors thus preventing SMAD2 access. Functions as an adapter to recruit SMURF2 to the TGF-beta receptor complex. Also acts by recruiting the PPP1R15A-PP1 complex to TGFBR1, which promotes its dephosphorylation. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator. The protein encoded by this gene is a nuclear protein that binds the E3 ubiquitin ligase SMURF2. Upon binding, this complex translocates to the cytoplasm, where it interacts with TGF-beta receptor type-1 (TGFBR1), leading to the degradation of both the encoded protein and TGFBR1. Expression of this gene is induced by TGFBR1. Variations in this gene are a cause of susceptibility to colorectal cancer type 3 (CRCS3). Several trans ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262158
  • ENSP00000262158
  • ENSG00000101665
  • ENST00000589634
  • ENSP00000467621
  • ENST00000591805
  • ENSP00000466902

Symbol
  • MADH7
  • MADH8
  • CRCS3
  • MADH7
  • MADH8
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
molecular function
0.96
hub protein
0.95
PubMedID
0.95
gene perturbation
0.94


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 906.06   (req: < 5)
Gene RIFs: 221   (req: <= 3)
Antibodies: 485   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 906.06   (req: >= 5)
Gene RIFs: 221   (req: > 3)
Antibodies: 485   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 48
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (19)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
14
5
0
1.2
99.8
heel bone mineral density
2
4
4
95.4
1
1
0
1.2
86.4
hemoglobin measurement
3
2
3
85.3
hematocrit
3
1
3
78.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.2
99.8
heel bone mineral density
4
95.4
0
1.2
86.4
hemoglobin measurement
3
85.3
hematocrit
3
78.6
Protein Data Bank (7)
1 – 5 of 7
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (41)
Deubiquitination (R-HSA-5688426)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 16
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Deubiquitination
Reactome
Downregulation of TGF-beta receptor signaling
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Deubiquitination
Downregulation of TGF-beta receptor signaling
Gene expression (Transcription)
Generic Transcription Pathway
Metabolism of proteins
Gene Ontology Terms (57)
Items per page:
10
1 – 10 of 10
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (215)
1 – 10 of 215
PRMT7
Tchem
Family: Epigenetic
Novelty: 0.02310897
p_int: 0.999800923
p_ni: 0.00019844
p_wrong: 6.37e-7
Data Source: BioPlex
PSMG2
Tbio
Novelty: 0.11082503
p_int: 0.999596782
p_ni: 0.000401536
p_wrong: 0.000001681
Data Source: BioPlex
DCAF16
Tdark
Novelty: 0.35666992
p_int: 0.998359488
p_ni: 0.001495942
p_wrong: 0.00014457
Data Source: BioPlex
NEDD4L
Tbio
Family: Enzyme
Novelty: 0.00250567
p_int: 0.996099614
p_ni: 0.003900386
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
PSMG1
Tbio
Novelty: 0.08175356
p_int: 0.992985448
p_ni: 0.007014552
Data Source: BioPlex
VNN1
Tchem
Family: Enzyme
Novelty: 0.0144646
p_int: 0.982927725
p_ni: 2.53e-7
p_wrong: 0.017072022
Data Source: BioPlex
ITCH
Tbio
Family: Enzyme
Novelty: 0.00681861
p_int: 0.961489627
p_ni: 0.038510373
Score: 0.803
Data Source: BioPlex,STRINGDB
WWP1
Tbio
Family: Enzyme
Novelty: 0.01407874
p_int: 0.899371217
p_ni: 0.100628782
Score: 0.983
Data Source: BioPlex,STRINGDB
RPS3
Tbio
Novelty: 0.003106
p_int: 0.793233852
p_ni: 0.206766148
Data Source: BioPlex
SMURF1
Tchem
Family: Enzyme
Novelty: 0.00754708
Score: 0.999
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  906.06

PubMed score by year
PubTator Score  407.3

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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