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Tbio
MTUS1
Microtubule-associated tumor suppressor 1

Protein Summary
Description
Cooperates with AGTR2 to inhibit ERK2 activation and cell proliferation. May be required for AGTR2 cell surface expression. Together with PTPN6, induces UBE2V2 expression upon angiotensin-II stimulation. Isoform 1 inhibits breast cancer cell proliferation, delays the progression of mitosis by prolonging metaphase and reduces tumor growth. This gene encodes a protein which contains a C-terminal domain able to interact with the angiotension II (AT2) receptor and a large coiled-coil region allowing dimerization. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. One of the transcript variants has been shown to encode a mitochondrial protein that acts as a tumor suppressor and partcipates in AT2 signaling pathways. Other variants may encode nuclear or transmembrane proteins but it has not been determined whether they also participate in AT2 signaling pathways. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262102
  • ENSP00000262102
  • ENSG00000129422
  • ENST00000297488
  • ENSP00000297488
  • ENST00000381861
  • ENSP00000371285
  • ENST00000381869
  • ENSP00000371293
  • ENST00000519263
  • ENSP00000430167
  • ENST00000544260
  • ENSP00000445738
  • ENST00000634613
  • ENSP00000489288

Symbol
  • ATBP
  • ATIP
  • GK1
  • KIAA1288
  • MTSG1
  • ATBP
  • ATIP
  • ICIS
  • MP44
  • ATIP3
  • MTSG1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.89
kinase perturbation
0.84
transcription factor perturbation
0.84
microRNA
0.82
transcription factor
0.79


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 102.68   (req: < 5)
Gene RIFs: 27   (req: <= 3)
Antibodies: 200   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 102.68   (req: >= 5)
Gene RIFs: 27   (req: > 3)
Antibodies: 200   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Gene Ontology Terms (12)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (43)
1 – 10 of 43
SKP1
Tbio
Family: Enzyme
Novelty: 0.00149739
p_int: 0.99999998
p_ni: 2e-8
Data Source: BioPlex
MTUS2
Tbio
Novelty: 0.13504593
p_int: 0.999992111
p_ni: 0.000007887
p_wrong: 1e-9
Score: 0.199
Data Source: BioPlex,STRINGDB
FHL3
Tbio
Novelty: 0.11505924
p_int: 0.999895063
p_ni: 0.000098395
p_wrong: 0.000006542
Score: 0.222
Data Source: BioPlex,STRINGDB
CLUH
Tbio
Novelty: 0.14027296
p_int: 0.869667972
p_ni: 0.130332027
Score: 0.248
Data Source: BioPlex,STRINGDB
KIF2C
Tbio
Novelty: 0.00498643
Score: 0.902
Data Source: STRINGDB
AGTR2
Tchem
Family: GPCR
Novelty: 0.00064774
Score: 0.77
Data Source: STRINGDB
PMFBP1
Tdark
Novelty: 0.25081073
Score: 0.69
Data Source: STRINGDB
SPATA4
Tbio
Novelty: 0.11011458
Score: 0.669
Data Source: STRINGDB
BDKRB2
Tclin
Family: GPCR
Novelty: 0.00335227
Score: 0.638
Data Source: STRINGDB
AURKB
Tchem
Family: Kinase
Novelty: 0.00100972
Score: 0.633
Data Source: STRINGDB
Publication Statistics
PubMed Score  102.68

PubMed score by year
PubTator Score  46.1

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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