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Tbio
RAB27B
Ras-related protein Rab-27B

Protein Summary
Description
Plays a role in NTRK2/TRKB axonal anterograde transport by facilitating the associaton of NTRK2/TRKB with KLC1 (PubMed:21775604). May be involved in targeting uroplakins to urothelial apical membranes (By similarity). Members of the Rab protein family, including RAB27B, are prenylated, membrane-bound proteins involved in vesicular fusion and trafficking (Chen et al., 1997 [PubMed 9066979]).[supplied by OMIM, Nov 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262094
  • ENSP00000262094
  • ENSG00000041353

Symbol
  • C25KG
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.96
transcription factor perturbation
0.91
histone modification site profile
0.76
microRNA
0.72
disease perturbation
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 72.79   (req: < 5)
Gene RIFs: 23   (req: <= 3)
Antibodies: 247   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 72.79   (req: >= 5)
Gene RIFs: 23   (req: > 3)
Antibodies: 247   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
4
3
4
95.8
unipolar depression
4
3
1
1
95.6
wellbeing measurement
4
4
6
94.6
neuroticism measurement
2
3
2
6.1
92.4
depressive symptom measurement
2
2
2
90.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
4
95.8
unipolar depression
1
1
95.6
wellbeing measurement
6
94.6
neuroticism measurement
2
6.1
92.4
depressive symptom measurement
2
90.8
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (13)
Hemostasis (R-HSA-109582)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Hemostasis
Reactome
Membrane Trafficking
Reactome
Metabolism of proteins
Reactome
Platelet activation, signaling and aggregation
Reactome
Platelet degranulation
Name
Explore in Pharos
Explore in Source
Hemostasis
Membrane Trafficking
Metabolism of proteins
Platelet activation, signaling and aggregation
Platelet degranulation
Gene Ontology Terms (26)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Protein-Protein Interactions (116)
1 – 10 of 116
SYTL2
Tbio
Novelty: 0.06704802
p_int: 1
Score: 0.838
Data Source: BioPlex,STRINGDB
SYTL4
Tbio
Novelty: 0.03934385
p_int: 1
Score: 0.807
Data Source: BioPlex,STRINGDB
SYTL1
Tbio
Novelty: 0.09070371
p_int: 1
Score: 0.653
Data Source: BioPlex,STRINGDB
RAB27A
Tchem
Family: Enzyme
Novelty: 0.00369416
p_int: 0.99999998
p_ni: 1.3e-8
p_wrong: 7e-9
Score: 0.905
Data Source: BioPlex,STRINGDB
SYTL5
Tbio
Novelty: 0.15102067
p_int: 0.999999901
p_wrong: 9.9e-8
Score: 0.76
Data Source: BioPlex,STRINGDB
CCDC186
Tdark
Novelty: 0.44973807
p_int: 0.999979541
p_ni: 0.000020451
p_wrong: 8e-9
Score: 0.219
Data Source: BioPlex,STRINGDB
SYTL3
Tbio
Novelty: 0.04849748
p_int: 0.999957489
p_ni: 1.62e-7
p_wrong: 0.000042349
Score: 0.587
Data Source: BioPlex,STRINGDB
CHM
Tbio
Family: Enzyme
Novelty: 0.00226278
p_int: 0.999929573
p_ni: 0.000070426
Score: 0.937
Data Source: BioPlex,STRINGDB
BDH2
Tbio
Family: Enzyme
Novelty: 0.04118875
p_int: 0.989433105
p_ni: 0.010566895
Score: 0.189
Data Source: BioPlex,STRINGDB
GBA
Tclin
Family: Enzyme
Novelty: 0.00051172
p_int: 0.95592092
p_ni: 0.04407908
Score: 0.374
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  72.79

PubMed score by year
PubTator Score  37.83

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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