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Tbio
ANAPC5
Anaphase-promoting complex subunit 5

Protein Summary
Description
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. This gene encodes a tetratricopeptide repeat-containing component of the anaphase promoting complex/cyclosome (APC/C), a large E3 ubiquitin ligase that controls cell cycle progression by targeting a number of cell cycle regulators such as B-type cyclins for 26S proteasome-mediated degradation through ubiquitination. The encoded protein is required for the proper ubiquitination function of APC/C and for the interaction of APC/C with transcription coactivators. It also interacts with polyA binding protein and represses internal ribosome entry site- ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000261819
  • ENSP00000261819
  • ENSG00000089053
  • ENST00000441917
  • ENSP00000415061

Symbol
  • APC5
  • APC5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
1
disease perturbation
1
kinase perturbation
1
transcription factor perturbation
1
virus perturbation
0.95


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 43.63   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 329   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 43.63   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 329   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
C-reactive protein measurement
1
1
1
69.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
C-reactive protein measurement
1
69.7
Protein Data Bank (9)
1 – 5 of 9
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (63)
APC-Cdc20 mediated degradation of Nek2A (R-HSA-179409)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 37
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
APC-Cdc20 mediated degradation of Nek2A
Reactome
APC/C-mediated degradation of cell cycle proteins
Reactome
APC/C:Cdc20 mediated degradation of Cyclin B
Reactome
APC/C:Cdc20 mediated degradation of Securin
Reactome
APC/C:Cdc20 mediated degradation of mitotic proteins
Name
Explore in Pharos
Explore in Source
APC-Cdc20 mediated degradation of Nek2A
APC/C-mediated degradation of cell cycle proteins
APC/C:Cdc20 mediated degradation of Cyclin B
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdc20 mediated degradation of mitotic proteins
Gene Ontology Terms (12)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (413)
1 – 10 of 413
ANAPC2
Tbio
Family: Enzyme
Novelty: 0.19812984
p_int: 0.999999992
p_ni: 8e-9
Score: 0.999
Data Source: BioPlex,STRINGDB
ANAPC4
Tbio
Family: Enzyme
Novelty: 0.28937094
p_int: 0.999999985
p_ni: 1.5e-8
Score: 0.999
Data Source: BioPlex,STRINGDB
CDC27
Tbio
Novelty: 0.00589846
p_int: 0.999999549
p_ni: 4.51e-7
Score: 0.999
Data Source: BioPlex,STRINGDB
NEK2
Tchem
Family: Kinase
Novelty: 0.0059613
p_int: 0.999998968
p_ni: 0.000001011
p_wrong: 2.1e-8
Score: 0.927
Data Source: BioPlex,STRINGDB
ANAPC1
Tbio
Family: Enzyme
Novelty: 0.0521845
p_int: 0.999997816
p_ni: 0.000002184
Score: 0.999
Data Source: BioPlex,STRINGDB
CDC23
Tbio
Novelty: 0.0168525
p_int: 0.99999748
p_ni: 0.000002516
p_wrong: 4e-9
Score: 0.999
Data Source: BioPlex,STRINGDB
FBXO5
Tbio
Novelty: 0.01571484
p_int: 0.999996927
p_ni: 8.85e-7
p_wrong: 0.000002188
Score: 0.924
Data Source: BioPlex,STRINGDB
CDC16
Tbio
Novelty: 0.00916715
p_int: 0.999996427
p_ni: 0.000003573
Score: 0.999
Data Source: BioPlex,STRINGDB
CDC26
Tbio
Family: Enzyme
Novelty: 0.07456358
p_int: 0.999995545
p_ni: 0.000004171
p_wrong: 2.84e-7
Score: 0.999
Data Source: BioPlex,STRINGDB
ANAPC13
Tbio
Family: Enzyme
Novelty: 0.06125489
p_int: 0.999994955
p_ni: 0.000005045
Score: 0.999
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  43.63

PubMed score by year
PubTator Score  17.5

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer