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Tclin
PDGFRB
Platelet-derived growth factor receptor beta

Protein Summary
Description
Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. Plays a role in the migration of vascular smooth muscle cells and the formation of neointima at vascular injury sites. Required for normal development of the cardiovascular system. Required for normal recruitment of pericytes (mesangial cells) in the kidney glomerulus, and for normal formation of a branched network of capillaries in kidney glomeruli. Promotes rearrangement of the actin cytoskeleton and the formation of membrane ruffles. Binding of its cognate ligands - homodimeric PDGFB, heterodimers formed by PDGFA and PDGFB or homodimeric PDGF ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000261799
  • ENSP00000261799
  • ENSG00000113721

Symbol
  • PDGFR
  • PDGFR1
  • IMF1
  • KOGS
  • IBGC4
  • JTK12
  • PDGFR
  • PENTT
  • CD140B
  • PDGFR1
  • PDGFR-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
biological term
1
molecular function
1
protein domain
1
hub protein
0.99


Related Tools
ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1162.68   (req: < 5)
Gene RIFs: 273   (req: <= 3)
Antibodies: 1897   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1162.68   (req: >= 5)
Gene RIFs: 273   (req: > 3)
Antibodies: 1897   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 77
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 336
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 10
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
2
2
2
90.8
monocyte percentage of leukocytes
2
2
2
74.6
granulocyte percentage of myeloid white cells
1
1
1
59.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
2
90.8
monocyte percentage of leukocytes
2
74.6
granulocyte percentage of myeloid white cells
1
59.6
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
platelet derived growth factor receptor beta
711353
Mouse
MGI:97531
18596
Rat
RGD:3285
24629
Dog
platelet derived growth factor receptor beta
VGNC:44373
442985
Horse
platelet derived growth factor receptor beta
VGNC:21262
100071665
Species
Name
OMA
EggNOG
Inparanoid
Macaque
platelet derived growth factor receptor beta
Mouse
Rat
Dog
platelet derived growth factor receptor beta
Horse
platelet derived growth factor receptor beta
Protein Structure (9 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P09619-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 9
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (91)
Constitutive Signaling by Aberrant PI3K in Cancer (R-HSA-2219530)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 20
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Constitutive Signaling by Aberrant PI3K in Cancer
Reactome
Cytokine Signaling in Immune system
Reactome
Disease
Reactome
Diseases of signal transduction
Reactome
Downstream signal transduction
Name
Explore in Pharos
Explore in Source
Constitutive Signaling by Aberrant PI3K in Cancer
Cytokine Signaling in Immune system
Disease
Diseases of signal transduction
Downstream signal transduction
Gene Ontology Terms (91)
Items per page:
10
1 – 10 of 16
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (411)
1 – 10 of 411
DEPDC1
Tbio
Novelty: 0.04255829
p_int: 0.999995785
p_ni: 0.000004214
p_wrong: 1e-9
Data Source: BioPlex
ATR
Tchem
Family: Kinase
Novelty: 0.00196978
p_int: 0.999990954
p_ni: 0.000009046
Score: 0.287
Data Source: BioPlex,STRINGDB
FOXK2
Tbio
Family: TF
Novelty: 0.01420141
p_int: 0.999854582
p_ni: 0.000145417
p_wrong: 1e-9
Score: 0.157
Data Source: BioPlex,STRINGDB
ANKLE2
Tbio
Novelty: 0.0995907
p_int: 0.999838575
p_ni: 0.000161425
Data Source: BioPlex
FOXK1
Tbio
Family: TF
Novelty: 0.01321144
p_int: 0.99853614
p_ni: 0.00146386
Score: 0.167
Data Source: BioPlex,STRINGDB
ACVR2B
Tchem
Family: Kinase
Novelty: 0.00555742
p_int: 0.992799723
p_ni: 0.007179071
p_wrong: 0.000021206
Score: 0.334
Data Source: BioPlex,STRINGDB
UBB
Tbio
Novelty: 0.00661254
p_int: 0.992174521
p_ni: 0.007825479
Score: 0.251
Data Source: BioPlex,STRINGDB
PDGFRA
Tclin
Family: Kinase
Novelty: 0.00066909
p_int: 0.978274992
p_ni: 0.000070685
p_wrong: 0.021654323
Score: 0.955
Data Source: BioPlex,Reactome,STRINGDB
ABCD4
Tbio
Family: Transporter
Novelty: 0.04096359
p_int: 0.968026955
p_ni: 0.031973018
p_wrong: 2.7e-8
Score: 0.183
Data Source: BioPlex,STRINGDB
NOP9
Tdark
Novelty: 2.89535198
p_int: 0.951294394
p_ni: 0.048705606
Data Source: BioPlex
Publication Statistics
PubMed Score  1162.68

PubMed score by year
PubTator Score  1112.72

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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