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Tclin
SLC6A4
Sodium-dependent serotonin transporter

Protein Summary
Description
Serotonin transporter whose primary function in the central nervous system involves the regulation of serotonergic signaling via transport of serotonin molecules from the synaptic cleft back into the pre-synaptic terminal for re-utilization. Plays a key role in mediating regulation of the availability of serotonin to other receptors of serotonergic systems. Terminates the action of serotonin and recycles it in a sodium-dependent manner. This gene encodes an integral membrane protein that transports the neurotransmitter serotonin from synaptic spaces into presynaptic neurons. The encoded protein terminates the action of serotonin and recycles it in a sodium-dependent manner. This protein is a target of psychomotor stimulants, such as amphetamines and cocaine, and is a member of the sodium:neurotransmitter symporter family. A repeat length polymorphism in the promoter of this gene has been shown to affect the rate of serotonin uptake and may play a role in sudden infant death syndrome, a ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000261707
  • ENSP00000261707
  • ENSG00000108576
  • ENST00000401766
  • ENSP00000385822

Symbol
  • HTT
  • SERT
  • HTT
  • 5HTT
  • OCD1
  • SERT
  • 5-HTT
  • SERT1
  • hSERT
  • 5-HTTLPR
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug
1
molecular function
1
disease
0.99
biological process
0.93
kinase
0.87


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6240.36   (req: < 5)
Gene RIFs: 1633   (req: <= 3)
Antibodies: 300   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6240.36   (req: >= 5)
Gene RIFs: 1633   (req: > 3)
Antibodies: 300   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 38
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 3357
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 66
Approved Drugs (66)
1 – 10 of 66
clozapine
chemical structure image
olanzapine
chemical structure image
risperidone
chemical structure image
cocaine
chemical structure image
aripiprazole
chemical structure image
chlorpromazine
chemical structure image
fluoxetine
chemical structure image
ziprasidone
chemical structure image
imatinib
chemical structure image
duloxetine
chemical structure image
Active Ligands (3357)
1 – 10 of 3357
CHEMBL295698
chemical structure image
CHEMBL1909072
chemical structure image
CHEMBL2079586
chemical structure image
CHEMBL478
chemical structure image
CHEMBL83729,CHEMBL1790051
chemical structure image
CHEMBL15928
chemical structure image
CHEMBL183460
chemical structure image
CHEMBL528995
chemical structure image
CHEMBL295467
chemical structure image
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
visceral adipose tissue measurement
1
1
1
64.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
visceral adipose tissue measurement
1
64.4
Protein Data Bank (10)
1 – 5 of 10
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (21)
Neuronal System (R-HSA-112316)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Neuronal System
Reactome
Neurotransmitter clearance
Reactome
Serotonin clearance from the synaptic cleft
Reactome
Transmission across Chemical Synapses
Name
Explore in Pharos
Explore in Source
Neuronal System
Neurotransmitter clearance
Serotonin clearance from the synaptic cleft
Transmission across Chemical Synapses
Gene Ontology Terms (48)
Items per page:
10
1 – 10 of 11
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (154)
1 – 10 of 154
HTR1A
Tclin
Family: GPCR
Novelty: 0.00015658
Score: 0.962
Data Source: STRINGDB
TPH1
Tclin
Family: Enzyme
Novelty: 0.00098637
Score: 0.913
Data Source: STRINGDB
HTR7
Tclin
Family: GPCR
Novelty: 0.00169884
Score: 0.913
Data Source: STRINGDB
COMT
Tclin
Family: Enzyme
Novelty: 0.00025107
Score: 0.913
Data Source: STRINGDB
HTR2A
Tclin
Family: GPCR
Novelty: 0.00035566
Score: 0.907
Data Source: STRINGDB
MAOA
Tclin
Family: Enzyme
Novelty: 0.00031037
Score: 0.899
Data Source: STRINGDB
SLC18A2
Tclin
Family: Transporter
Novelty: 0.00072341
Score: 0.893
Data Source: STRINGDB
HTR1B
Tclin
Family: GPCR
Novelty: 0.00073663
Score: 0.873
Data Source: STRINGDB
HTR2C
Tclin
Family: GPCR
Novelty: 0.00074287
Score: 0.862
Data Source: STRINGDB
TPH2
Tchem
Family: Enzyme
Novelty: 0.00265377
Score: 0.855
Data Source: STRINGDB
Publication Statistics
PubMed Score  6240.36

PubMed score by year
PubTator Score  3935

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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