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Tbio
SLC7A5
Large neutral amino acids transporter small subunit 1

Protein Summary
Description
Sodium-independent, high-affinity transport of large neutral amino acids such as phenylalanine, tyrosine, leucine, arginine and tryptophan, when associated with SLC3A2/4F2hc. Involved in cellular amino acid uptake. Acts as an amino acid exchanger. Involved in the transport of L-DOPA across the blood-brain barrier, and that of thyroid hormones triiodothyronine (T3) and thyroxine (T4) across the cell membrane in tissues such as placenta. Plays a role in neuronal cell proliferation (neurogenesis) in brain. Involved in the uptake of methylmercury (MeHg) when administered as the L-cysteine or D,L-homocysteine complexes, and hence plays a role in metal ion homeostasis and toxicity. Involved in the cellular activity of small molecular weight nitrosothiols, via the stereoselective transport of L-nitrosocysteine (L-CNSO) across the transmembrane. May play an important role in high-grade gliomas. Mediates blood-to-retina L-leucine transport across the inner blood-retinal barrier which in turn ma ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000261622
  • ENSP00000261622
  • ENSG00000103257

Symbol
  • CD98LC
  • LAT1
  • MPE16
  • E16
  • CD98
  • LAT1
  • 4F2LC
  • MPE16
  • D16S469E
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
1
kinase perturbation
0.96
transcription factor binding site profile
0.9
interacting protein
0.86
PubMedID
0.79


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 260.24   (req: < 5)
Gene RIFs: 112   (req: <= 3)
Antibodies: 351   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 260.24   (req: >= 5)
Gene RIFs: 112   (req: > 3)
Antibodies: 351   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
1
1
1
83.2
blood metabolite measurement
1
1
1
73.8
mean reticulocyte volume
1
1
1
58.2
mean corpuscular volume
1
1
1
57.3
chronic central serous retinopathy
1
1
0
2.1
56.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
1
83.2
blood metabolite measurement
1
73.8
mean reticulocyte volume
1
58.2
mean corpuscular volume
1
57.3
chronic central serous retinopathy
0
2.1
56.7
Pathways (21)
Amino acid transport across the plasma membrane (R-HSA-352230)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Amino acid transport across the plasma membrane
Reactome
Basigin interactions
Reactome
Cell surface interactions at the vascular wall
Reactome
Hemostasis
Reactome
Metabolism
Name
Explore in Pharos
Explore in Source
Amino acid transport across the plasma membrane
Basigin interactions
Cell surface interactions at the vascular wall
Hemostasis
Metabolism
Gene Ontology Terms (16)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (81)
1 – 10 of 81
SLC3A2
Tbio
Family: Transporter
Novelty: 0.0021506
Score: 0.995
Data Source: Reactome,STRINGDB
BSG
Tbio
Novelty: 0.0010285
Score: 0.915
Data Source: STRINGDB
SLC1A5
Tchem
Family: Transporter
Novelty: 0.00201741
Score: 0.834
Data Source: STRINGDB
SLC1A7
Tchem
Family: Transporter
Novelty: 0.00067678
Score: 0.828
Data Source: STRINGDB
SLC1A4
Tbio
Family: Transporter
Novelty: 0.01334316
Score: 0.765
Data Source: STRINGDB
SLC43A1
Tbio
Family: Transporter
Novelty: 0.06939259
Score: 0.751
Data Source: STRINGDB
SLC38A2
Tbio
Family: Transporter
Novelty: 0.00808235
Score: 0.737
Data Source: STRINGDB
SLC38A1
Tbio
Family: Transporter
Novelty: 0.01350134
Score: 0.734
Data Source: STRINGDB
MTOR
Tclin
Family: Kinase
Novelty: 0.00012333
Score: 0.719
Data Source: STRINGDB
FGD6
Tbio
Novelty: 0.07213159
Score: 0.711
Data Source: STRINGDB
Publication Statistics
PubMed Score  260.24

PubMed score by year
PubTator Score  284.88

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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