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Tbio
PPP2R3C
Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma

Protein Classes
Protein Summary
Description
May regulate MCM3AP phosphorylation through phosphatase recruitment. May act as a negative regulator of ABCB1 expression and function through the dephosphorylation of ABCB1 by TFPI2/PPP2R3C complex. May play a role in the activation-induced cell death of B-cells. This gene encodes a regulatory subunit of the serine/threonine phosphatase, protein phosphatase 2. This protein is localized to both nuclear and cytoplasmic regions depending on cell cycle phase. Homozygous conditional knockout mice for this gene exhibit reduced numbers and impaired proliferation of immune system B cells. This protein may regulate the expression of the P-glycoprotein ATP-binding cassette transporter through its phosphatase activity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000261475
  • ENSP00000261475
  • ENSG00000092020

Symbol
  • C14orf10
  • G5PR
  • G4-1
  • G5pr
  • C14orf10
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.91
transcription factor binding site profile
0.87
transcription factor perturbation
0.8
biological process
0.72
kinase perturbation
0.71


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.77   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 151   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.77   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 151   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.1
74.7
lymphocyte count
2
2
2
61
monocyte percentage of leukocytes
2
2
2
59.6
monocyte count
1
1
1
43.1
neutrophil percentage of leukocytes
1
1
1
30.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
74.7
lymphocyte count
2
61
monocyte percentage of leukocytes
2
59.6
monocyte count
1
43.1
neutrophil percentage of leukocytes
1
30.2
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
protein phosphatase 2 regulatory subunit B''gamma
VGNC:10313
452859
Macaque
protein phosphatase 2 regulatory subunit B''gamma
694616
Mouse
MGI:1930009
59032
Rat
RGD:1309207
362739
Dog
protein phosphatase 2 regulatory subunit B''gamma
VGNC:44912
480289
Species
Name
OMA
EggNOG
Inparanoid
Chimp
protein phosphatase 2 regulatory subunit B''gamma
Macaque
protein phosphatase 2 regulatory subunit B''gamma
Mouse
Rat
Dog
protein phosphatase 2 regulatory subunit B''gamma
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q969Q6-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (106)
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
KEGG
PI3K-Akt signaling pathway
KEGG
Dopaminergic synapse
KEGG
mRNA surveillance pathway
KEGG
AMPK signaling pathway
KEGG
Adrenergic signaling in cardiomyocytes
Name
Explore in Pharos
Explore in Source
PI3K-Akt signaling pathway
Dopaminergic synapse
mRNA surveillance pathway
AMPK signaling pathway
Adrenergic signaling in cardiomyocytes
Gene Ontology Terms (16)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (102)
1 – 10 of 102
CEP19
Tbio
Novelty: 0.20749222
p_int: 0.999999995
p_ni: 3e-9
p_wrong: 2e-9
Data Source: BioPlex
FGFR1OP
Tbio
Novelty: 0.09922864
p_int: 0.999999992
p_ni: 1e-9
p_wrong: 7e-9
Score: 0.857
Data Source: BioPlex,STRINGDB
PPP2CB
Tbio
Family: Enzyme
Novelty: 0.0483178
p_int: 0.999999917
p_ni: 8.2e-8
p_wrong: 1e-9
Score: 0.906
Data Source: BioPlex,STRINGDB
PPP2R1A
Tbio
Family: Enzyme
Novelty: 0.01134139
p_int: 0.999995933
p_ni: 0.00000403
p_wrong: 3.7e-8
Score: 0.703
Data Source: BioPlex,STRINGDB
PIP
Tbio
Novelty: 0.00208509
p_int: 0.999995028
p_ni: 0.000004956
p_wrong: 1.6e-8
Data Source: BioPlex
ORC5
Tbio
Novelty: 0.02264865
Score: 0.852
Data Source: STRINGDB
PPP2R5C
Tbio
Family: Enzyme
Novelty: 0.03336609
Score: 0.838
Data Source: STRINGDB
PPP2R5E
Tbio
Family: Enzyme
Novelty: 0.05974697
Score: 0.838
Data Source: STRINGDB
PPP2R5A
Tchem
Family: Enzyme
Novelty: 0.03073487
Score: 0.836
Data Source: STRINGDB
PPP2R5B
Tbio
Family: Enzyme
Novelty: 0.08980945
Score: 0.832
Data Source: STRINGDB
Publication Statistics
PubMed Score  31.77

PubMed score by year
PubTator Score  14.43

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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