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Tchem
IRAK3
Interleukin-1 receptor-associated kinase 3

Protein Summary
Description
Inhibits dissociation of IRAK1 and IRAK4 from the Toll-like receptor signaling complex by either inhibiting the phosphorylation of IRAK1 and IRAK4 or stabilizing the receptor complex. This gene encodes a member of the interleukin-1 receptor-associated kinase protein family. Members of this family are essential components of the Toll/IL-R immune signal transduction pathways. This protein is primarily expressed in monocytes and macrophages and functions as a negative regulator of Toll-like receptor signaling. Mutations in this gene are associated with a susceptibility to asthma. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000261233
  • ENSP00000261233
  • ENSG00000090376
  • ENST00000457197
  • ENSP00000409852

Symbol
  • ASRT5
  • IRAKM
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.98
biological process
0.97
PubMedID
0.84
tissue sample
0.7
histone modification site profile
0.67


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 121.76   (req: < 5)
Gene RIFs: 39   (req: <= 3)
Antibodies: 518   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 121.76   (req: >= 5)
Gene RIFs: 39   (req: > 3)
Antibodies: 518   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 30
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 3
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
crizotinib
chemical structure image
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (110)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Interleukin-1 family signaling
Reactome
Interleukin-1 signaling
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Immune System
Innate Immune System
Interleukin-1 family signaling
Interleukin-1 signaling
Gene Ontology Terms (33)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Protein-Protein Interactions (82)
1 – 10 of 82
CD44
Tbio
Novelty: 0.00011321
p_int: 0.999984325
p_ni: 0.000015562
p_wrong: 1.12e-7
Score: 0.263
Data Source: BioPlex,STRINGDB
DPP8
Tchem
Family: Enzyme
Novelty: 0.00678793
p_int: 0.999927193
p_ni: 0.000072807
Data Source: BioPlex
HSPB8
Tbio
Novelty: 0.00298618
p_int: 0.999885915
p_ni: 0.00002936
p_wrong: 0.000084726
Data Source: BioPlex
TBK1
Tchem
Family: Kinase
Novelty: 0.00194753
p_int: 0.991671418
p_ni: 0.008328582
Score: 0.361
Data Source: BioPlex,STRINGDB
AZI2
Tbio
Novelty: 0.23255317
p_int: 0.987415372
p_ni: 0.000576863
p_wrong: 0.012007764
Score: 0.189
Data Source: BioPlex,STRINGDB
FKBP5
Tchem
Family: Enzyme
Novelty: 0.00214511
p_int: 0.949113402
p_ni: 0.050886598
Score: 0.192
Data Source: BioPlex,STRINGDB
MYD88
Tbio
Novelty: 0.00037931
Score: 0.995
Data Source: STRINGDB
IRAK4
Tchem
Family: Kinase
Novelty: 0.00344058
Score: 0.989
Data Source: STRINGDB
IRAK1
Tchem
Family: Kinase
Novelty: 0.00170873
Score: 0.985
Data Source: STRINGDB
IRAK2
Tbio
Family: Kinase
Novelty: 0.01496024
Score: 0.985
Data Source: STRINGDB
Publication Statistics
PubMed Score  121.76

PubMed score by year
PubTator Score  63.29

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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