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Tclin
ABCC9
ATP-binding cassette sub-family C member 9

Protein Summary
Description
Subunit of ATP-sensitive potassium channels (KATP). Can form cardiac and smooth muscle-type KATP channels with KCNJ11. KCNJ11 forms the channel pore while ABCC9 is required for activation and regulation. The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein is thought to form ATP-sensitive potassium channels in cardiac, skeletal, and vascular and non-vascular smooth muscle. Protein structure suggests a role as the drug-binding channel-modulating subunit of the extra-pancreatic ATP-sensitive potassium channels. Mutations in this gene are associated with cardiomyopathy dilated type 1O. Alternative splicing results in multiple transcript variants. [pro ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000261200
  • ENSP00000261200
  • ENSG00000069431
  • ENST00000261201
  • ENSP00000261201

Symbol
  • SUR2
  • SUR2
  • ABC37
  • CANTU
  • CMD1O
  • ATFB12
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
1
protein domain
0.92
disease perturbation
0.83
cell line
0.72
phenotype
0.72


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 66.08   (req: < 5)
Gene RIFs: 34   (req: <= 3)
Antibodies: 215   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 66.08   (req: >= 5)
Gene RIFs: 34   (req: > 3)
Antibodies: 215   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 10
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2
Approved Drugs (2)
1 – 2 of 2
minoxidil
chemical structure image
pinacidil
chemical structure image
Active Ligands (10)
1 – 10 of 10
CHEMBL454166
chemical structure image
CHEMBL491479
chemical structure image
CHEMBL508050
chemical structure image
CHEMBL473941
chemical structure image
CHEMBL473744
chemical structure image
CHEMBL454168
chemical structure image
CHEMBL454369
chemical structure image
CHEMBL11458
chemical structure image
CHEMBL455407
chemical structure image
CHEMBL455408
chemical structure image
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hippocampal sclerosis of aging
1
1
0
2.1
66.8
pulse pressure measurement
1
1
1
62.8
appendicular lean mass
2
1
2
59.8
parental genotype effect measurement
1
1
1
18.6
birth weight
1
1
1
18.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hippocampal sclerosis of aging
0
2.1
66.8
pulse pressure measurement
1
62.8
appendicular lean mass
2
59.8
parental genotype effect measurement
1
18.6
birth weight
1
18.6
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ATP binding cassette subfamily C member 9
VGNC:12752
465338
Macaque
ATP binding cassette subfamily C member 9
654489
Mouse
MGI:1352630
20928
Rat
RGD:3787
25560
Dog
ATP binding cassette subfamily C member 9
VGNC:37444
486638
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ATP binding cassette subfamily C member 9
Macaque
ATP binding cassette subfamily C member 9
Mouse
Rat
Dog
ATP binding cassette subfamily C member 9
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-O60706-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (14)
ABC transporter disorders (R-HSA-5619084)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 13
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ABC transporter disorders
Reactome
ABC-family proteins mediated transport
Reactome
ATP sensitive Potassium channels
Reactome
Cardiac conduction
Reactome
Defective ABCC9 causes dilated cardiomyopathy 10, familial atrial fibrillation 12 and hypertrichotic osteochondrodysplasia
Name
Explore in Pharos
Explore in Source
ABC transporter disorders
ABC-family proteins mediated transport
ATP sensitive Potassium channels
Cardiac conduction
Defective ABCC9 causes dilated cardiomyopathy 10, familial atrial fibrillation 12 and hypertrichotic osteochondrodysplasia
Gene Ontology Terms (18)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (82)
1 – 10 of 82
KCNJ8
Tbio
Family: IC
Novelty: 0.00369886
Score: 0.993
Data Source: Reactome,STRINGDB
KCNJ11
Tclin
Family: IC
Novelty: 0.00068183
Score: 0.989
Data Source: Reactome,STRINGDB
ABCC8
Tclin
Family: Transporter
Novelty: 0.00085572
Score: 0.727
Data Source: STRINGDB
ABCA9
Tbio
Family: Transporter
Novelty: 0.09458742
Score: 0.611
Data Source: STRINGDB
RBM20
Tbio
Novelty: 0.02126441
Score: 0.588
Data Source: STRINGDB
ABCA8
Tbio
Family: Transporter
Novelty: 0.0698037
Score: 0.577
Data Source: STRINGDB
KCNE5
Tbio
Novelty: 0.06395873
Score: 0.575
Data Source: STRINGDB
SCN5A
Tclin
Family: IC
Novelty: 0.00050944
Score: 0.574
Data Source: STRINGDB
ITM2C
Tbio
Novelty: 0.10829732
Score: 0.563
Data Source: STRINGDB
CSRP3
Tbio
Novelty: 0.00892632
Score: 0.559
Data Source: STRINGDB
Publication Statistics
PubMed Score  66.08

PubMed score by year
PubTator Score  87.39

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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