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Tclin
MSTN
Growth/differentiation factor 8

Protein Summary
Description
Acts specifically as a negative regulator of skeletal muscle growth. This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein negatively regulates skeletal muscle cell proliferation and differentiation. Mutations in this gene are associated with increased skeletal muscle mass in humans and other mammals. [provided by RefSeq, Jul 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000260950
  • ENSP00000260950
  • ENSG00000138379

Symbol
  • GDF8
  • GDF8
  • MSLHP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.99
gene perturbation
0.85
protein domain
0.85
biological term
0.83
cell type or tissue
0.7


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1894.07   (req: < 5)
Gene RIFs: 134   (req: <= 3)
Antibodies: 732   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1894.07   (req: >= 5)
Gene RIFs: 134   (req: > 3)
Antibodies: 732   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 38
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
luspatercept
no chemical structure image available
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
myostatin
VGNC:14156
470605
Macaque
myostatin
710114
Mouse
MGI:95691
17700
Rat
RGD:3115
29152
Dog
myostatin
VGNC:43453
403433
Species
Name
OMA
EggNOG
Inparanoid
Chimp
myostatin
Macaque
myostatin
Mouse
Rat
Dog
myostatin
Protein Structure (4 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O14793-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (199)
FOXO-mediated transcription (R-HSA-9614085)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
FOXO-mediated transcription
Reactome
FOXO-mediated transcription of cell cycle genes
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
RNA Polymerase II Transcription
Name
Explore in Pharos
Explore in Source
FOXO-mediated transcription
FOXO-mediated transcription of cell cycle genes
Gene expression (Transcription)
Generic Transcription Pathway
RNA Polymerase II Transcription
Gene Ontology Terms (40)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (147)
1 – 10 of 147
FST
Tbio
Novelty: 0.00085875
Score: 0.99
Data Source: STRINGDB
ACVR2B
Tchem
Family: Kinase
Novelty: 0.00555742
Score: 0.97
Data Source: STRINGDB
FSTL3
Tbio
Novelty: 0.01238701
Score: 0.969
Data Source: STRINGDB
MYOD1
Tbio
Family: TF
Novelty: 0.00053412
Score: 0.91
Data Source: STRINGDB
WFIKKN2
Tbio
Novelty: 0.15855407
Score: 0.883
Data Source: STRINGDB
IGF1
Tbio
Novelty: 0.00003878
Score: 0.848
Data Source: STRINGDB
MYOG
Tbio
Family: TF
Novelty: 0.00074867
Score: 0.846
Data Source: STRINGDB
FBXO32
Tbio
Novelty: 0.00225437
Score: 0.844
Data Source: STRINGDB
SMAD3
Tbio
Family: TF
Novelty: 0.00048058
Score: 0.841
Data Source: STRINGDB
ACVR2A
Tchem
Family: Kinase
Novelty: 0.0063932
Score: 0.841
Data Source: STRINGDB
Publication Statistics
PubMed Score  1894.07

PubMed score by year
PubTator Score  323.88

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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