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Tbio
TTLL7
Tubulin polyglutamylase TTLL7

Protein Summary
Description
Polyglutamylase which preferentially modifies beta-tubulin (PubMed:25959773). Mediates both ATP-dependent initiation and elongation of polyglutamylation of microtubules (PubMed:25959773). Required for neurite growth; responsible for the strong increase in tubulin polyglutamylation during postnatal neuronal maturation (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000260505
  • ENSP00000260505
  • ENSG00000137941
  • ENST00000480174
  • ENSP00000435334
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.79
cell line
0.56
tissue
0.55
gene perturbation
0.54
tissue sample
0.52


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.72   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 27   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.72   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 27   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (3)
Carboxyterminal post-translational modifications of tubulin (R-HSA-8955332)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Carboxyterminal post-translational modifications of tubulin
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Name
Explore in Pharos
Explore in Source
Carboxyterminal post-translational modifications of tubulin
Metabolism of proteins
Post-translational protein modification
Protein-Protein Interactions (22)
1 – 10 of 22
CSNK2A2
Tchem
Family: Kinase
Novelty: 0.00420757
p_int: 0.99833912
p_ni: 0.00166088
Score: 0.343
Data Source: BioPlex,STRINGDB
ZMYM1
Tdark
p_int: 0.995124445
p_ni: 0.004875549
p_wrong: 6e-9
Score: 0.214
Data Source: BioPlex,STRINGDB
CSNK2A1
Tchem
Family: Kinase
Novelty: 0.00124949
p_int: 0.96208692
p_ni: 0.037913079
p_wrong: 1e-9
Score: 0.666
Data Source: BioPlex,STRINGDB
MNS1
Tbio
Novelty: 0.06017877
Score: 0.606
Data Source: STRINGDB
RUFY4
Tbio
Novelty: 1.07142857
Score: 0.557
Data Source: STRINGDB
AGBL4
Tbio
Family: Enzyme
Novelty: 0.12261879
Score: 0.547
Data Source: STRINGDB
ZNF142
Tdark
Family: TF
Novelty: 0.45
Score: 0.541
Data Source: STRINGDB
ROPN1L
Tdark
Novelty: 0.32761751
Score: 0.535
Data Source: STRINGDB
MIGA1
Tbio
Novelty: 0.11180124
Score: 0.523
Data Source: STRINGDB
SLC44A5
Tdark
Family: Transporter
Novelty: 0.2384106
Score: 0.502
Data Source: STRINGDB
Publication Statistics
PubMed Score  12.72

PubMed score by year
PubTator Score  1.63

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer