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Tbio
THBS1
Thrombospondin-1

Protein Summary
Description
Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Binds heparin. May play a role in dentinogenesis and/or maintenance of dentin and dental pulp (By similarity). Ligand for CD36 mediating antiangiogenic properties. Plays a role in ER stress response, via its interaction with the activating transcription factor 6 alpha (ATF6) which produces adaptive ER stress response factors (By similarity). The protein encoded by this gene is a subunit of a disulfide-linked homotrimeric protein. This protein is an adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. This protein can bind to fibrinogen, fibronectin, laminin, type V collagen and integrins alpha-V/beta-1. This protein has been shown to play roles in platelet aggregation, angiogenesis, and tumorigenesis. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000260356
  • ENSP00000260356
  • ENSG00000137801

Symbol
  • TSP
  • TSP1
  • TSP
  • THBS
  • TSP1
  • TSP-1
  • THBS-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
biological term
1
protein domain
1
PubMedID
1
molecular function
0.98


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1569.89   (req: < 5)
Gene RIFs: 348   (req: <= 3)
Antibodies: 655   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1569.89   (req: >= 5)
Gene RIFs: 348   (req: > 3)
Antibodies: 655   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 83
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urate measurement
1
1
1
27.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urate measurement
1
27.7
Protein Data Bank (10)
1 – 5 of 10
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (135)
Defective B3GALTL causes Peters-plus syndrome (PpS) (R-HSA-5083635)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 24
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Defective B3GALTL causes Peters-plus syndrome (PpS)
Reactome
Disease
Reactome
Diseases associated with O-glycosylation of proteins
Reactome
Diseases of glycosylation
Reactome
Extracellular matrix organization
Name
Explore in Pharos
Explore in Source
Defective B3GALTL causes Peters-plus syndrome (PpS)
Disease
Diseases associated with O-glycosylation of proteins
Diseases of glycosylation
Extracellular matrix organization
Gene Ontology Terms (97)
Items per page:
10
1 – 10 of 14
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Mutant Phenotype (IMP)
BHF-UCL
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Protein-Protein Interactions (357)
1 – 10 of 357
THBS2
Tbio
Novelty: 0.00310724
p_int: 1
Score: 0.942
Data Source: BioPlex,STRINGDB
THBS3
Tbio
Novelty: 0.01915634
p_int: 0.999998576
p_ni: 4.9e-8
p_wrong: 0.000001376
Score: 0.238
Data Source: BioPlex,STRINGDB
FCGRT
Tchem
Novelty: 0.00105713
p_int: 0.9999972
p_ni: 0.0000028
Score: 0.191
Data Source: BioPlex,STRINGDB
DDX31
Tbio
Family: Enzyme
Novelty: 2.84646195
p_int: 0.999969539
p_ni: 0.000030447
p_wrong: 1.3e-8
Data Source: BioPlex
CD47
Tchem
Novelty: 0.00129086
Score: 0.992
Data Source: STRINGDB
VEGFA
Tclin
Novelty: 0.0000378
Score: 0.99
Data Source: STRINGDB
FN1
Tchem
Novelty: 0.00003647
Score: 0.982
Data Source: STRINGDB
TGFB1
Tchem
Novelty: 0.0001299
Score: 0.981
Data Source: STRINGDB
TIMP1
Tbio
Family: Enzyme
Novelty: 0.00020986
Score: 0.978
Data Source: STRINGDB
VWF
Tbio
Novelty: 0.00009007
Score: 0.978
Data Source: STRINGDB
Publication Statistics
PubMed Score  1569.89

PubMed score by year
PubTator Score  2123.39

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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