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Tchem
TTPA
Alpha-tocopherol transfer protein

Protein Summary
Description
Binds alpha-tocopherol, enhances its transfer between separate membranes, and stimulates its release from liver cells (PubMed:7887897). Binds both phosphatidylinol 3,4-bisphosphate and phosphatidylinol 4,5-bisphosphate; the resulting conformation change is important for the release of the bound alpha-tocopherol (By similarity). This gene encodes a soluble protein that binds alpha-trocopherol, a form of vitamin E, with high selectivity and affinity. This protein plays an important role in regulating vitamin E levels in the body by transporting vitamin E between membrane vesicles and facilitating the secretion of vitamin E from hepatocytes to circulating lipoproteins. Mutations in this gene cause hereditary vitamin E deficiency (ataxia with vitamin E deficiency, AVED) and retinitis pigmentosa. [provided by RefSeq, Nov 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000260116
  • ENSP00000260116
  • ENSG00000137561

Symbol
  • TPP1
  • ATTP
  • AVED
  • TTP1
  • alphaTTP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.72
molecular function
0.63
cell type or tissue
0.61
kinase perturbation
0.6
microRNA
0.6


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 301.1   (req: < 5)
Gene RIFs: 25   (req: <= 3)
Antibodies: 107   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 301.1   (req: >= 5)
Gene RIFs: 25   (req: > 3)
Antibodies: 107   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (1)
1 – 1 of 1
CHEMBL247483
chemical structure image
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
alpha tocopherol transfer protein
VGNC:10488
472778
Mouse
MGI:1354168
50500
Rat
RGD:3915
25571
Dog
alpha tocopherol transfer protein
VGNC:47981
403627
Horse
alpha tocopherol transfer protein [Source:HGNC Symbol;Acc:HGNC:12404]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
alpha tocopherol transfer protein
Mouse
Rat
Dog
alpha tocopherol transfer protein
Horse
alpha tocopherol transfer protein [Source:HGNC Symbol;Acc:HGNC:12404]
Protein Structure (5 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P49638-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 5
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (4)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of fat-soluble vitamins
Reactome
Metabolism of vitamins and cofactors
Reactome
Vitamin E
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of fat-soluble vitamins
Metabolism of vitamins and cofactors
Vitamin E
Gene Ontology Terms (17)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Protein-Protein Interactions (31)
1 – 10 of 31
ATCAY
Tbio
Novelty: 0.08312317
Score: 0.8
Data Source: STRINGDB
PRUNE2
Tbio
Novelty: 0.05701865
Score: 0.748
Data Source: STRINGDB
FXN
Tbio
Novelty: 0.00084064
Score: 0.71
Data Source: STRINGDB
SRR
Tbio
Family: Enzyme
Novelty: 0.00425993
Score: 0.704
Data Source: STRINGDB
RRS1
Tbio
Novelty: 0.01643671
Score: 0.7
Data Source: STRINGDB
TRIM37
Tbio
Family: Enzyme
Novelty: 0.02515451
Score: 0.676
Data Source: STRINGDB
SLC6A11
Tbio
Family: Transporter
Novelty: 0.01324279
Score: 0.652
Data Source: STRINGDB
BNIP2
Tbio
Novelty: 0.01260537
Score: 0.641
Data Source: STRINGDB
CYP4F2
Tchem
Family: Enzyme
Novelty: 0.0050361
Score: 0.622
Data Source: STRINGDB
EIF3K
Tbio
Novelty: 0.04938688
Score: 0.621
Data Source: STRINGDB
Publication Statistics
PubMed Score  301.10

PubMed score by year
PubTator Score  101.26

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer