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Tbio
PI15
Peptidase inhibitor 15

Protein Summary
Description
Serine protease inhibitor which displays weak inhibitory activity against trypsin (PubMed:8882727). May play a role in facial patterning during embryonic development (By similarity). This gene encodes a trypsin inhibitor. The protein shares similarity to insect venom allergens, mammalian testis-specific proteins and plant pathogenesis-related proteins. It is frequently expressed in human neuroblastoma and glioblastoma cell lines, and thus may play a role in the central nervous system. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000260113
  • ENSP00000260113
  • ENSG00000137558
  • ENST00000523773
  • ENSP00000428567
  • ENST00000649643
  • ENSP00000497041

Symbol
  • CRISP8
  • P25TI
  • P24TI
  • P25TI
  • CRISP8
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
microRNA
0.82
gene perturbation
0.53
tissue sample
0.52
cell line
0.5
cell type or tissue
0.47


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 42.13   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 175   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 42.13   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 175   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Gene Ontology Terms (4)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (46)
1 – 10 of 46
KIAA0319L
Tbio
Novelty: 0.02873675
p_int: 0.999987866
p_ni: 0.000012134
Data Source: BioPlex
GLS
Tchem
Family: Enzyme
Novelty: 0.00321692
p_int: 0.999961534
p_ni: 0.000038466
Data Source: BioPlex
MRM2
Tbio
Family: Enzyme
Novelty: 0.06394065
p_int: 0.999959422
p_ni: 0.000003748
p_wrong: 0.000036831
Data Source: BioPlex
MIB2
Tbio
Family: Enzyme
Novelty: 0.044378
p_int: 0.999931305
p_ni: 0.000068666
p_wrong: 2.9e-8
Data Source: BioPlex
CCNH
Tbio
Novelty: 0.00693072
p_int: 0.999915859
p_ni: 0.000084013
p_wrong: 1.28e-7
Data Source: BioPlex
SUPT6H
Tbio
Novelty: 0.01099565
p_int: 0.997827041
p_ni: 0.002172959
Data Source: BioPlex
TRIM37
Tbio
Family: Enzyme
Novelty: 0.02515451
p_int: 0.991216303
p_ni: 0.008035367
p_wrong: 0.00074833
Data Source: BioPlex
MNAT1
Tbio
Family: Enzyme
Novelty: 0.02484936
p_int: 0.988625489
p_ni: 0.01137451
Data Source: BioPlex
CHD8
Tbio
Family: Epigenetic
Novelty: 0.01177693
p_int: 0.965538055
p_ni: 0.034461945
Data Source: BioPlex
MTMR1
Tbio
Family: Enzyme
Novelty: 0.06694505
p_int: 0.846715206
p_ni: 0.153199263
p_wrong: 0.000085531
Data Source: BioPlex
Publication Statistics
PubMed Score  42.13

PubMed score by year
PubTator Score  8.09

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer