Protein Summary
Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides (PubMed:21078852, PubMed:17889651). Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. May also activate immune cells and promote apoptosis in response to the lipid moiety of lipoproteins (PubMed:10426995, PubMed:10426996). Recognizes mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2), soluble tuberculosis factor (STF), phenol-soluble modulin (PSM) and B.burgdorferi outer surface protein A lipoprotein (OspA-L) cooperatively with TLR6 (PubMed:11441107). Stimulation of monocytes in vitro with M.tuberculosis PstS1 induces p38 MAPK and ERK1/2 activation primarily via this receptor, but also partially via TLR4 (PubMed:16622205). MAPK activation in response to bacterial peptidoglycan also occur ...more
- ENST00000260010
- ENSP00000260010
- ENSG00000137462
- ENST00000642580
- ENSP00000495339
- ENST00000642700
- ENSP00000494425
- ENST00000644308
- ENSP00000496321
- TIL4
- TIL4
- CD282
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
biological process | 1 | ||
biological term | 1 | ||
virus perturbation | 1 | ||
protein domain | 0.85 | ||
disease | 0.84 | ||
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 4123.96 (req: < 5)
Gene RIFs: 1164 (req: <= 3)
Antibodies: 1225 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 4123.96 (req: >= 5)
Gene RIFs: 1164 (req: > 3)
Antibodies: 1225 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 68
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 6
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Active Ligands (6)
1 – 6 of 6
Protein Data Bank (5)
1 – 5 of 5
PDB Structure Id | Ligand | Method | Resolution (Ã…) | M.W. (kDa) | Pub Year | Title |
---|
PDB Structure Id | M.W. | Resolution | Pub Year |
---|
Pathways (55)
Reactome (22)
KEGG (19)
PathwayCommons (2)
WikiPathways (12)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 22
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Adaptive Immune System | ||||
Reactome | Antigen processing-Cross presentation | ||||
Reactome | Antimicrobial peptides | ||||
Reactome | Beta defensins | ||||
Reactome | Class I MHC mediated antigen processing & presentation | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Adaptive Immune System | ||||
Antigen processing-Cross presentation | ||||
Antimicrobial peptides | ||||
Beta defensins | ||||
Class I MHC mediated antigen processing & presentation | ||||
Gene Ontology Terms (80)
Functions (11)
Components (12)
Processes (57)
Items per page:
10
1 – 10 of 11
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | ARUK-UCL | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | MGI | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | MGI | |||
Inferred from Physical Interaction (IPI) | IntAct | |||
Inferred from Physical Interaction (IPI) | ARUK-UCL | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Traceable Author Statement (TAS) | UniProtKB | |||
Protein-Protein Interactions (555)
1 – 10 of 555
STAT5A
Family: TF
Novelty: 0.00091229
p_int: 0.99999948
p_ni: 5.2e-7
Score: 0.531
Data Source: BioPlex,STRINGDB
TMEM214
Novelty: 1.5
p_int: 0.975242989
p_ni: 0.024757011
Data Source: BioPlex
ACVR2A
Family: Kinase
Novelty: 0.007745
p_int: 0.944150669
p_ni: 0.055088187
p_wrong: 0.000761144
Score: 0.247
Data Source: BioPlex,STRINGDB
BMPR1A
Family: Kinase
Novelty: 0.00472897
p_int: 0.904940777
p_ni: 0.058923062
p_wrong: 0.036136161
Score: 0.25
Data Source: BioPlex,STRINGDB
ITPRIP
Novelty: 0.31547929
p_int: 0.841237631
p_ni: 0.158762369
Score: 0.179
Data Source: BioPlex,STRINGDB
USP33
Family: Enzyme
Novelty: 0.06317232
p_int: 0.814331969
p_ni: 0.185668003
p_wrong: 2.8e-8
Score: 0.154
Data Source: BioPlex,STRINGDB
STK11IP
Family: Enzyme
Novelty: 0.50209205
p_int: 0.804157927
p_ni: 0.195842073
Score: 0.188
Data Source: BioPlex,STRINGDB
LGR4
Family: GPCR
Novelty: 0.01548681
p_int: 0.77703092
p_ni: 0.221896428
p_wrong: 0.001072652
Score: 0.212
Data Source: BioPlex,STRINGDB
AP1M1
Novelty: 0.05716619
p_int: 0.762342178
p_ni: 0.237657822
Score: 0.239
Data Source: BioPlex,STRINGDB
TLR1
Novelty: 0.00100796
Score: 0.995
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score 4123.96
PubMed score by year
PubTator Score 2503.5
PubTator score by year
Amino Acid Sequence
Residue Counts
Sequence
MPHTLWMVWVLGVIISLSKEESSNQASLSCDRNGICKGSSGSLNSIPSGLTEAVKSLDLSNNRITYISNS
1-70
DLQRCVNLQALVLTSNGINTIEEDSFSSLGSLEHLDLSYNYLSNLSSSWFKPLSSLTFLNLLGNPYKTLG
70-140
ETSLFSHLTKLQILRVGNMDTFTKIQRKDFAGLTFLEELEIDASDLQSYEPKSLKSIQNVSHLILHMKQH
140-210
ILLLEIFVDVTSSVECLELRDTDLDTFHFSELSTGETNSLIKKFTFRNVKITDESLFQVMKLLNQISGLL
210-280
ELEFDDCTLNGVGNFRASDNDRVIDPGKVETLTIRRLHIPRFYLFYDLSTLYSLTERVKRITVENSKVFL
280-350
VPCLLSQHLKSLEYLDLSENLMVEEYLKNSACEDAWPSLQTLILRQNHLASLEKTGETLLTLKNLTNIDI
350-420
SKNSFHSMPETCQWPEKMKYLNLSSTRIHSVTGCIPKTLEILDVSNNNLNLFSLNLPQLKELYISRNKLM
420-490
TLPDASLLPMLLVLKISRNAITTFSKEQLDSFHTLKTLEAGGNNFICSCEFLSFTQEQQALAKVLIDWPA
490-560
NYLCDSPSHVRGQQVQDVRLSVSECHRTALVSGMCCALFLLILLTGVLCHRFHGLWYMKMMWAWLQAKRK
560-630
PRKAPSRNICYDAFVSYSERDAYWVENLMVQELENFNPPFKLCLHKRDFIPGKWIIDNIIDSIEKSHKTV
630-700
FVLSENFVKSEWCKYELDFSHFRLFDENNDAAILILLEPIEKKAIPQRFCKLRKIMNTKTYLEWPMDEAQ
700-770
REGFWVNLRAAIKS
770-784
MPHTLWMVWVLGVIISLSKEESSNQASLSCDRNGICKGSSGSLNSIPSGLTEAVKSLDLSNNRITYISNSDLQRCVNLQALVLTSNGINTIEEDSFSSLGSLEHLDLSYNYLSNLSSSWFKPLSSLTFLNLLGNPYKTLGETSLFSHLTKLQILRVGNMDTFTKIQRKDFAGLTFLEELEIDASDLQSYEPKSLKSIQNVSHLILHMKQHILLLEIFVDVTSSVECLELRDTDLDTFHFSELSTGETNSLIKKFTFRNVKITDESLFQVMKLLNQISGLLELEFDDCTLNGVGNFRASDNDRVIDPGKVETLTIRRLHIPRFYLFYDLSTLYSLTERVKRITVENSKVFLVPCLLSQHLKSLEYLDLSENLMVEEYLKNSACEDAWPSLQTLILRQNHLASLEKTGETLLTLKNLTNIDISKNSFHSMPETCQWPEKMKYLNLSSTRIHSVTGCIPKTLEILDVSNNNLNLFSLNLPQLKELYISRNKLMTLPDASLLPMLLVLKISRNAITTFSKEQLDSFHTLKTLEAGGNNFICSCEFLSFTQEQQALAKVLIDWPANYLCDSPSHVRGQQVQDVRLSVSECHRTALVSGMCCALFLLILLTGVLCHRFHGLWYMKMMWAWLQAKRKPRKAPSRNICYDAFVSYSERDAYWVENLMVQELENFNPPFKLCLHKRDFIPGKWIIDNIIDSIEKSHKTVFVLSENFVKSEWCKYELDFSHFRLFDENNDAAILILLEPIEKKAIPQRFCKLRKIMNTKTYLEWPMDEAQREGFWVNLRAAIKS
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