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Tbio
TMOD1
Tropomodulin-1

Protein Summary
Description
Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton. May play an important role in regulating the organization of actin filaments by preferentially binding to a specific tropomyosin isoform at its N-terminus. This gene encodes a member of the tropomodulin family. The encoded protein is an actin-capping protein that regulates tropomyosin by binding to its N-terminus, inhibiting depolymerization and elongation of the pointed end of actin filaments and thereby influencing the structure of the erythrocyte membrane skeleton. Multiple transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Oct 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000259365
  • ENSP00000259365
  • ENSG00000136842
  • ENST00000375175
  • ENSP00000364318
  • ENST00000395211
  • ENSP00000378637

Symbol
  • D9S57E
  • TMOD
  • TMOD
  • ETMOD
  • D9S57E
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
ligand (protein) perturbation
0.83
microRNA
0.82
gene perturbation
0.8
cell type or tissue
0.69
transcription factor
0.65


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 107.58   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 239   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 107.58   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 239   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
2
2
2
62.9
2
1
0
1.1
44.2
1
1
0
2.4
30
1
1
0
1.1
29.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
2
62.9
0
1.1
44.2
0
2.4
30
0
1.1
29.8
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
tropomodulin 1
VGNC:4884
464599
Macaque
tropomodulin 1
715838
Mouse
MGI:98775
21916
Rat
RGD:3874
25566
Dog
tropomodulin 1
VGNC:47623
474771
Species
Name
OMA
EggNOG
Inparanoid
Chimp
tropomodulin 1
Macaque
tropomodulin 1
Mouse
Rat
Dog
tropomodulin 1
Protein Structure (5 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P28289-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 5
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (7)
Muscle contraction (R-HSA-397014)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Muscle contraction
Reactome
Striated Muscle Contraction
Name
Explore in Pharos
Explore in Source
Muscle contraction
Striated Muscle Contraction
Gene Ontology Terms (16)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (99)
1 – 10 of 99
MYO5B
Tbio
Novelty: 0.01302142
p_int: 0.999999491
p_ni: 5.08e-7
p_wrong: 1e-9
Score: 0.271
Data Source: BioPlex,STRINGDB
LRRFIP1
Tbio
Novelty: 0.02584638
p_int: 0.999999151
p_ni: 8.49e-7
Score: 0.696
Data Source: BioPlex,STRINGDB
SCIN
Tbio
Novelty: 0.0080322
p_int: 0.999998849
p_ni: 0.00000115
Score: 0.809
Data Source: BioPlex,STRINGDB
LRRFIP2
Tbio
Novelty: 0.15492934
p_int: 0.999950674
p_ni: 0.000049326
Score: 0.592
Data Source: BioPlex,STRINGDB
FLII
Tbio
Novelty: 0.00200219
p_int: 0.999904543
p_ni: 0.000095457
Score: 0.76
Data Source: BioPlex,STRINGDB
MYO5C
Tbio
Novelty: 0.05680943
p_int: 0.994039484
p_ni: 0.005960516
Score: 0.489
Data Source: BioPlex,STRINGDB
AGTPBP1
Tbio
Family: Enzyme
Novelty: 0.01925456
p_int: 0.989437573
p_ni: 0.0003112
p_wrong: 0.010251227
Score: 0.527
Data Source: BioPlex,STRINGDB
NIN
Tbio
Novelty: 0.01312714
p_int: 0.987725145
p_ni: 0.012077536
p_wrong: 0.000197319
Score: 0.167
Data Source: BioPlex,STRINGDB
GSN
Tbio
Novelty: 0.00060852
p_int: 0.987392351
p_ni: 0.012607649
Score: 0.802
Data Source: BioPlex,STRINGDB
SNX1
Tbio
Novelty: 0.01267973
p_int: 0.950871043
p_ni: 0.049128954
p_wrong: 3e-9
Score: 0.151
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  107.58

PubMed score by year
PubTator Score  38.42

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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