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Tbio
CCDC115
Coiled-coil domain-containing protein 115

Protein Summary
Description
Accessory component of the proton-transporting vacuolar (V)-ATPase protein pump involved in intracellular iron homeostasis. In aerobic conditions, required for intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation. Necessary for endolysosomal acidification and lysosomal degradation (PubMed:28296633). May be involved in Golgi homeostasis (PubMed:26833332). The protein encoded by this gene has been observed to localize to the endoplasmic reticulum (ER)-Golgi intermediate compartment (ERGIC) and coat protein complex I (COPI) vesicles in some human cells. The encoded protein shares some homology with the yeast V-ATPase assembly factor Vma22p, and the orthologous protein in mouse promotes cell proliferation and suppresses cell death. Defects in this gene are a cause of congenital disorder of glycosylation, type IIo in humans. [provided by RefSeq, Mar 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000259229
  • ENSP00000259229
  • ENSG00000136710

Symbol
  • ccp1
  • CDG2O
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.88
transcription factor binding site profile
0.83
cell type or tissue
0.6
transcription factor
0.6
tissue
0.58


Related Tools
GENEVA
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.24   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 63   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.24   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 63   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
coiled-coil domain containing 115
VGNC:121
459603
Mouse
MGI:1916918
69668
Rat
RGD:1304653
363213
Dog
coiled-coil domain containing 115
VGNC:38784
606806
Horse
coiled-coil domain containing 115
VGNC:16112
106781893
Species
Name
OMA
EggNOG
Inparanoid
Chimp
coiled-coil domain containing 115
Mouse
Rat
Dog
coiled-coil domain containing 115
Horse
coiled-coil domain containing 115
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q96NT0-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (13)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (91)
1 – 10 of 91
ATP6V0A2
Tbio
Family: Enzyme
Novelty: 0.00504614
p_int: 0.999940176
p_ni: 0.000059565
p_wrong: 2.59e-7
Score: 0.916
Data Source: BioPlex,STRINGDB
ATP6V0D2
Tbio
Family: Enzyme
Novelty: 0.0354396
p_int: 0.999890442
p_ni: 0.000105609
p_wrong: 0.00000395
Score: 0.986
Data Source: BioPlex,STRINGDB
PLXDC2
Tbio
Novelty: 0.06496695
p_int: 0.999874434
p_ni: 0.00012545
p_wrong: 1.16e-7
Score: 0.243
Data Source: BioPlex,STRINGDB
KIAA2013
Tdark
Novelty: 0.4705158
p_int: 0.999561302
p_ni: 0.000288367
p_wrong: 0.000150331
Score: 0.817
Data Source: BioPlex,STRINGDB
ATP6AP2
Tbio
Novelty: 0.00357665
p_int: 0.999216923
p_ni: 0.000614604
p_wrong: 0.000168473
Score: 0.845
Data Source: BioPlex,STRINGDB
TSPAN17
Tdark
Novelty: 0.51639684
p_int: 0.999124886
p_ni: 0.000647598
p_wrong: 0.000227516
Score: 0.294
Data Source: BioPlex,STRINGDB
ATP6V0D1
Tbio
Family: Enzyme
Novelty: 0.05146108
p_int: 0.998888939
p_ni: 0.000514825
p_wrong: 0.000596236
Score: 0.982
Data Source: BioPlex,STRINGDB
ATP6V0E1
Tbio
Family: Enzyme
Novelty: 0.076209
p_int: 0.998673354
p_ni: 0.001180554
p_wrong: 0.000146092
Score: 0.783
Data Source: BioPlex,STRINGDB
TMEM199
Tbio
Novelty: 0.05799147
p_int: 0.987917513
p_ni: 0.003851778
p_wrong: 0.008230709
Score: 0.996
Data Source: BioPlex,STRINGDB
TGFA
Tbio
Novelty: 0.00216159
p_int: 0.9852797
p_ni: 0.000241223
p_wrong: 0.014479077
Data Source: BioPlex
Publication Statistics
PubMed Score  4.24

PubMed score by year
PubTator Score  25.05

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer