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Tchem
BLK
Tyrosine-protein kinase Blk

Protein Summary
Description
Non-receptor tyrosine kinase involved in B-lymphocyte development, differentiation and signaling. B-cell receptor (BCR) signaling requires a tight regulation of several protein tyrosine kinases and phosphatases, and associated coreceptors. Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activation. Signaling through BLK plays an important role in transmitting signals through surface immunoglobulins and supports the pro-B to pre-B transition, as well as the signaling for growth arrest and apoptosis downstream of B-cell receptor. Specifically binds and phosphorylates CD79A at 'Tyr-188'and 'Tyr-199', as well as CD79B at 'Tyr-196' and 'Tyr-207'. Phosphorylates also the immunoglobulin G receptors FCGR2A, FCGR2B and FCGR2C. With FYN and LYN, plays an essential role in pre-B-cell receptor (pre-BCR)-mediated NF-kappa-B activation. Contributes also to BTK activation by indirectly stimulating BTK intramolecular autophosphorylation. In pa ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000259089
  • ENSP00000259089
  • ENSG00000136573

Symbol
  • MODY11
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
small molecule
0.99
molecular function
0.94
protein domain
0.92
biological process
0.82
cell type or tissue
0.68


Related Tools
ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 186.95   (req: < 5)
Gene RIFs: 54   (req: <= 3)
Antibodies: 537   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 186.95   (req: >= 5)
Gene RIFs: 54   (req: > 3)
Antibodies: 537   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 20
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 4
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neuroticism measurement
2
5
5
5.5
96.1
heel bone mineral density
1
1
1
91
4
3
0
1.4
85.4
1
1
0
1.3
59.7
1
1
0
1.3
48.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neuroticism measurement
5
5.5
96.1
heel bone mineral density
1
91
0
1.4
85.4
0
1.3
59.7
0
1.3
48.3
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
BLK proto-oncogene, Src family tyrosine kinase
463991
Macaque
BLK proto-oncogene, Src family tyrosine kinase
696892
Mouse
MGI:88169
12143
Rat
RGD:1308859
364403
Dog
BLK proto-oncogene, Src family tyrosine kinase
VGNC:38464
486080
Species
Name
OMA
EggNOG
Inparanoid
Chimp
BLK proto-oncogene, Src family tyrosine kinase
Macaque
BLK proto-oncogene, Src family tyrosine kinase
Mouse
Rat
Dog
BLK proto-oncogene, Src family tyrosine kinase
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P51451-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (24)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Gene expression (Transcription)
Generic Transcription Pathway
Immune System
Protein-Protein Interactions (210)
1 – 10 of 210
RNASE3
Tbio
Family: Enzyme
Novelty: 0.00059878
p_int: 0.990025375
p_ni: 0.001106052
p_wrong: 0.008868573
Score: 0.189
Data Source: BioPlex,STRINGDB
SYCP3
Tbio
Novelty: 0.00443901
p_int: 0.98493422
p_ni: 0.000251087
p_wrong: 0.014814692
Score: 0.517
Data Source: BioPlex,STRINGDB
FAM217B
Tdark
Novelty: 4.03122155
p_int: 0.963785313
p_ni: 0.033545616
p_wrong: 0.002669071
Score: 0.193
Data Source: BioPlex,STRINGDB
SENP1
Tchem
Family: Enzyme
Novelty: 0.00831213
p_int: 0.920782822
p_ni: 0.075040428
p_wrong: 0.004176751
Score: 0.213
Data Source: BioPlex,STRINGDB
APBB3
Tbio
Novelty: 0.15864948
p_int: 0.914133746
p_ni: 0.084184731
p_wrong: 0.001681523
Score: 0.165
Data Source: BioPlex,STRINGDB
EDEM2
Tbio
Family: Enzyme
Novelty: 0.1180208
p_int: 0.912040065
p_ni: 0.083354503
p_wrong: 0.004605432
Score: 0.197
Data Source: BioPlex,STRINGDB
C15orf53
Tdark
Novelty: 0.38036081
p_int: 0.889756029
p_ni: 0.10545414
p_wrong: 0.004789831
Data Source: BioPlex
TAGAP
Tbio
Family: Enzyme
Novelty: 0.04450409
p_int: 0.886837831
p_ni: 0.110105615
p_wrong: 0.003056554
Score: 0.358
Data Source: BioPlex,STRINGDB
CTNND1
Tbio
Novelty: 0.00335459
p_int: 0.879260099
p_ni: 0.116617942
p_wrong: 0.004121959
Data Source: BioPlex
KCNE1
Tbio
Family: IC
Novelty: 0.0015463
p_int: 0.857699794
p_ni: 0.13821141
p_wrong: 0.004088796
Data Source: BioPlex
Publication Statistics
PubMed Score  186.95

PubMed score by year
PubTator Score  84.24

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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