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Tbio
MTHFS
5-formyltetrahydrofolate cyclo-ligase

Protein Classes
Protein Summary
Description
Contributes to tetrahydrofolate metabolism. Helps regulate carbon flow through the folate-dependent one-carbon metabolic network that supplies carbon for the biosynthesis of purines, thymidine and amino acids. Catalyzes the irreversible conversion of 5-formyltetrahydrofolate (5-FTHF) to yield 5,10-methenyltetrahydrofolate. The protein encoded by this gene is an enzyme that catalyzes the conversion of 5-formyltetrahydrofolate to 5,10-methenyltetrahydrofolate, a precursor of reduced folates involved in 1-carbon metabolism. An increased activity of the encoded protein can result in an increased folate turnover rate and folate depletion. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jun 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000258874
  • ENSP00000258874
  • ENSG00000136371

Symbol
  • NEDMEHM
  • HsT19268
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.84
transcription factor binding site profile
0.68
cell type or tissue
0.66
transcription factor perturbation
0.61
tissue sample
0.6


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.08   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 215   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.08   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 215   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
methenyltetrahydrofolate synthetase
VGNC:14642
453578
Macaque
5,10-methenyltetrahydrofolate synthetase (5-formyltetrahydrofolate cyclo-ligase)
717493
Mouse
MGI:1340032
107885
Mouse
MGI:3780550
100039707
Rat
RGD:1306876
300886
Species
Name
OMA
EggNOG
Inparanoid
Chimp
methenyltetrahydrofolate synthetase
Macaque
5,10-methenyltetrahydrofolate synthetase (5-formyltetrahydrofolate cyclo-ligase)
Mouse
Mouse
Rat
Protein Structure (4 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P49914-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (10)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of folate and pterines
Reactome
Metabolism of vitamins and cofactors
Reactome
Metabolism of water-soluble vitamins and cofactors
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of folate and pterines
Metabolism of vitamins and cofactors
Metabolism of water-soluble vitamins and cofactors
Protein-Protein Interactions (33)
1 – 10 of 33
PLCL2
Tbio
Family: Enzyme
Novelty: 0.13454277
p_int: 0.973434524
p_ni: 0.000085257
p_wrong: 0.026480219
Score: 0.685
Data Source: BioPlex,STRINGDB
MTHFD1
Tbio
Family: Enzyme
Novelty: 0.0071938
Score: 0.971
Data Source: STRINGDB
GART
Tclin
Novelty: 0.00524985
Score: 0.962
Data Source: STRINGDB
MTHFD2
Tchem
Family: Enzyme
Novelty: 0.01776594
Score: 0.96
Data Source: STRINGDB
MTHFD2L
Tdark
Family: Enzyme
Novelty: 0.18530504
Score: 0.956
Data Source: STRINGDB
FTCD
Tbio
Family: Enzyme
Novelty: 0.02266041
Score: 0.944
Data Source: STRINGDB
ALDH1L1
Tbio
Family: Enzyme
Novelty: 0.01123871
Score: 0.928
Data Source: STRINGDB
GCSH
Tbio
Novelty: 0.02101972
Score: 0.74
Data Source: STRINGDB
FPGS
Tchem
Family: Enzyme
Novelty: 0.0108601
Score: 0.735
Data Source: STRINGDB
SHMT1
Tbio
Family: Enzyme
Novelty: 0.00200739
Score: 0.723
Data Source: STRINGDB
Publication Statistics
PubMed Score  36.08

PubMed score by year
PubTator Score  18.29

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer