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Tclin
HTR2B
5-hydroxytryptamine receptor 2B

Protein Summary
Description
G-protein coupled receptor for 5-hydroxytryptamine (serotonin) (PubMed:8143856, PubMed:7926008, PubMed:8078486, PubMed:8882600, PubMed:18703043, PubMed:23519210). Also functions as a receptor for various ergot alkaloid derivatives and psychoactive substances (PubMed:8143856, PubMed:7926008, PubMed:8078486, PubMed:12970106, PubMed:18703043, PubMed:23519210, PubMed:23519215, PubMed:24357322, PubMed:28129538). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors (PubMed:8143856, PubMed:8078486, PubMed:8882600, PubMed:23519215, PubMed:28129538). Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways (PubMed:23519215, PubMed:28129538). Signaling activates a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and down-stream signaling cascades and pr ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000258400
  • ENSP00000258400
  • ENSG00000135914

Symbol
  • 5-HT2B
  • 5-HT-2B
  • 5-HT(2B)
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
ligand (chemical)
1
drug
0.94
molecular function
0.88
gene perturbation
0.77


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 399.56   (req: < 5)
Gene RIFs: 36   (req: <= 3)
Antibodies: 368   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 399.56   (req: >= 5)
Gene RIFs: 36   (req: > 3)
Antibodies: 368   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 46
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 482
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 51
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
5-hydroxytryptamine receptor 2B
VGNC:7409
737647
Macaque
5-hydroxytryptamine receptor 2B
711808
Mouse
MGI:109323
15559
Rat
RGD:61801
29581
Dog
5-hydroxytryptamine receptor 2B
VGNC:41827
403881
Species
Name
OMA
EggNOG
Inparanoid
Chimp
5-hydroxytryptamine receptor 2B
Macaque
5-hydroxytryptamine receptor 2B
Mouse
Rat
Dog
5-hydroxytryptamine receptor 2B
Protein Structure (8 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P41595-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 8
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (18)
Amine ligand-binding receptors (R-HSA-375280)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Amine ligand-binding receptors
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (q) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Name
Explore in Pharos
Explore in Source
Amine ligand-binding receptors
Class A/1 (Rhodopsin-like receptors)
G alpha (q) signalling events
GPCR downstream signalling
GPCR ligand binding
Gene Ontology Terms (53)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Protein-Protein Interactions (191)
1 – 10 of 191
AGTR1
Tclin
Family: GPCR
Novelty: 0.00033439
Score: 0.948
Data Source: STRINGDB
GNAQ
Tbio
Novelty: 0.0008997
Score: 0.947
Data Source: STRINGDB
GNA11
Tbio
Novelty: 0.00128664
Score: 0.941
Data Source: STRINGDB
NTS
Tbio
Novelty: 0.00033201
Score: 0.938
Data Source: STRINGDB
EDN1
Tbio
Novelty: 0.00007453
Score: 0.936
Data Source: STRINGDB
TAC1
Tbio
Novelty: 0.00006575
Score: 0.926
Data Source: STRINGDB
GRM5
Tchem
Family: GPCR
Novelty: 0.00062552
Score: 0.926
Data Source: STRINGDB
GRM1
Tchem
Family: GPCR
Novelty: 0.00099764
Score: 0.926
Data Source: STRINGDB
NPS
Tbio
Novelty: 0.00692108
Score: 0.925
Data Source: STRINGDB
HCRT
Tbio
Novelty: 0.00034048
Score: 0.925
Data Source: STRINGDB
Publication Statistics
PubMed Score  399.56

PubMed score by year
PubTator Score  181.67

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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