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Tbio
DOCK10
Dedicator of cytokinesis protein 10

Protein Summary
Description
Guanine nucleotide-exchange factor (GEF) that activates CDC42 and RAC1 by exchanging bound GDP for free GTP. Essential for dendritic spine morphogenesis in Purkinje cells and in hippocampal neurons, via a CDC42-mediated pathway. Sustains B-cell lymphopoiesis in secondary lymphoid tissues and regulates FCER2/CD23 expression. This gene encodes a member of the dedicator of cytokinesis protein family. Members of this family are guanosine nucleotide exchange factors for Rho GTPases and defined by the presence of conserved DOCK-homology regions. The encoded protein belongs to the D (or Zizimin) subfamily of DOCK proteins, which also contain an N-terminal pleckstrin homology domain. Alternatively spliced transcript variants that encode different isoforms have been described. [provided by RefSeq, Mar 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000258390
  • ENSP00000258390
  • ENSG00000135905
  • ENST00000409592
  • ENSP00000386694

Symbol
  • KIAA0694
  • ZIZ3
  • ZIZ3
  • DRIP2
  • Nbla10300
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.92
ligand (protein) perturbation
0.83
PubMedID
0.75
transcription factor perturbation
0.61
histone modification site profile
0.56


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.53   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 52   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.53   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 52   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
3
3
3
89.3
lymphocyte count
2
2
2
69.9
self reported educational attainment
1
1
1
66.3
monocyte percentage of leukocytes
2
2
2
66.3
mean platelet volume
2
1
2
65
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
3
89.3
lymphocyte count
2
69.9
self reported educational attainment
1
66.3
monocyte percentage of leukocytes
2
66.3
mean platelet volume
2
65
Pathways (4)
Factors involved in megakaryocyte development and platelet production (R-HSA-983231)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Factors involved in megakaryocyte development and platelet production
Reactome
Hemostasis
Name
Explore in Pharos
Explore in Source
Factors involved in megakaryocyte development and platelet production
Hemostasis
Gene Ontology Terms (14)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Protein-Protein Interactions (32)
1 – 10 of 32
DOCK9
Tbio
Novelty: 0.07297324
p_int: 0.999999995
p_ni: 3e-9
p_wrong: 2e-9
Score: 0.697
Data Source: BioPlex,STRINGDB
HAL
Tbio
Family: Enzyme
Novelty: 0.01504631
p_int: 0.930382527
p_ni: 0.069617473
Score: 0.239
Data Source: BioPlex,STRINGDB
CDC42
Tchem
Family: Enzyme
Novelty: 0.00032619
Score: 0.975
Data Source: STRINGDB
RAC1
Tbio
Family: Enzyme
Novelty: 0.00365325
Score: 0.939
Data Source: STRINGDB
DHX37
Tdark
Family: Enzyme
Novelty: 0.02474351
Score: 0.833
Data Source: STRINGDB
DHX8
Tbio
Family: Enzyme
Novelty: 0.01584745
Score: 0.758
Data Source: STRINGDB
RHOJ
Tbio
Family: Enzyme
Novelty: 0.01217051
Score: 0.72
Data Source: STRINGDB
RHOF
Tbio
Family: Enzyme
Novelty: 0.01795771
Score: 0.684
Data Source: STRINGDB
C14orf28
Tbio
Novelty: 0.1574889
Score: 0.58
Data Source: STRINGDB
RHOQ
Tbio
Family: Enzyme
Novelty: 0.00562425
Score: 0.564
Data Source: STRINGDB
Publication Statistics
PubMed Score  11.53

PubMed score by year
PubTator Score  10.72

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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