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Tchem
RGS8
Regulator of G-protein signaling 8

Protein Summary
Description
Regulates G protein-coupled receptor signaling cascades, including signaling via muscarinic acetylcholine receptor CHRM2 and dopamine receptor DRD2 (By similarity). Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form (PubMed:18434541). Modulates the activity of potassium channels that are activated in response to DRD2 and CHRM2 signaling (By similarity). This gene is a member of the regulator of G protein signaling (RGS) family and encodes a protein with a single RGS domain. Regulator of G protein signaling (RGS) proteins are regulatory and structural components of G protein-coupled receptor complexes. They accelerate transit through the cycle of GTP binding and hydrolysis to GDP, thereby terminating signal transduction, but paradoxically, also accelerate receptor-stimulated activation. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000258302
  • ENSP00000258302
  • ENSG00000135824
  • ENST00000367556
  • ENSP00000356527
  • ENST00000367557
  • ENSP00000356528
  • ENST00000483095
  • ENSP00000426289
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.92
trait
0.75
tissue sample
0.64
PubMedID
0.58
disease
0.55


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.12   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 127   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.12   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 127   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 3
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (3)
1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (11)
G alpha (i) signalling events (R-HSA-418594)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Reactome
Signal Transduction
Reactome
Signaling by GPCR
Name
Explore in Pharos
Explore in Source
G alpha (i) signalling events
GPCR downstream signalling
Signal Transduction
Signaling by GPCR
Gene Ontology Terms (10)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Protein-Protein Interactions (59)
1 – 10 of 59
NXT2
Tdark
Novelty: 0.03767394
p_int: 0.999996433
p_ni: 0.000001053
p_wrong: 0.000002514
Score: 0.379
Data Source: BioPlex,STRINGDB
UBR2
Tbio
Family: Enzyme
Novelty: 0.03126228
p_int: 0.851235591
p_ni: 0.148764409
Score: 0.239
Data Source: BioPlex,STRINGDB
GNAI3
Tbio
Novelty: 0.03484857
Score: 0.99
Data Source: STRINGDB
GNAI1
Tbio
Novelty: 0.0488971
Score: 0.962
Data Source: STRINGDB
GNAI2
Tbio
Novelty: 0.03014729
Score: 0.943
Data Source: STRINGDB
GNAT3
Tbio
Novelty: 0.00702357
Score: 0.937
Data Source: STRINGDB
CHRM3
Tclin
Family: GPCR
Novelty: 0.00849776
Score: 0.77
Data Source: STRINGDB
NCDN
Tbio
Novelty: 0.04933873
Score: 0.765
Data Source: STRINGDB
GNAO1
Tbio
Novelty: 0.00315097
Score: 0.738
Data Source: STRINGDB
TACR1
Tclin
Family: GPCR
Novelty: 0.00062762
Score: 0.725
Data Source: STRINGDB
Publication Statistics
PubMed Score  31.12

PubMed score by year
PubTator Score  14.83

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer