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Tbio
EMX1
Homeobox protein EMX1

Protein Summary
Description
Transcription factor, which in cooperation with EMX2, acts to generate the boundary between the roof and archipallium in the developing brain. May function in combinations with OTX1/2 to specify cell fates in the developing central nervous system.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000258106
  • ENSP00000258106
  • ENSG00000135638
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.66
protein domain
0.58
PubMedID
0.58
histone modification site profile
0.51
transcription factor
0.49


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 168.46   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 184   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 168.46   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 184   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
1
0
1.1
76.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
76.2
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
empty spiracles homeobox 1
VGNC:243
738411
Mouse
MGI:95387
13796
Rat
RGD:1564002
500235
Cow
empty spiracles homeobox 1
VGNC:28485
539333
Pig
empty spiracles homeobox 1
100521187
Species
Name
OMA
EggNOG
Inparanoid
Chimp
empty spiracles homeobox 1
Mouse
Rat
Cow
empty spiracles homeobox 1
Pig
empty spiracles homeobox 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q04741-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Protein-Protein Interactions (70)
1 – 10 of 70
TBR1
Tbio
Family: TF
Novelty: 0.00676736
Score: 0.805
Data Source: STRINGDB
FOXG1
Tbio
Family: TF
Novelty: 0.00154897
Score: 0.755
Data Source: STRINGDB
TMPRSS6
Tchem
Family: Enzyme
Novelty: 0.00739906
Score: 0.658
Data Source: STRINGDB
ABCA3
Tbio
Family: Transporter
Novelty: 0.00376503
Score: 0.652
Data Source: STRINGDB
NEUROG2
Tbio
Family: TF
Novelty: 0.00489481
Score: 0.629
Data Source: STRINGDB
LHX5
Tbio
Family: TF
Novelty: 0.04947314
Score: 0.621
Data Source: STRINGDB
FEZF2
Tbio
Family: TF
Novelty: 0.01641588
Score: 0.599
Data Source: STRINGDB
BCL11B
Tbio
Family: TF
Novelty: 0.00555596
Score: 0.597
Data Source: STRINGDB
OLIG2
Tbio
Family: TF
Novelty: 0.0015221
Score: 0.592
Data Source: STRINGDB
NR2E1
Tbio
Family: NR
Novelty: 0.0184868
Score: 0.587
Data Source: STRINGDB
Publication Statistics
PubMed Score  168.46

PubMed score by year
PubTator Score  15.53

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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