You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
CCT7
T-complex protein 1 subunit eta

Protein Summary
Description
Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis (PubMed:25467444). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). The TRiC complex plays a role in the folding of actin and tubulin (Probable). This gene encodes a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 5 and 6. [provided by RefSeq, Oct 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000258091
  • ENSP00000258091
  • ENSG00000135624
  • ENST00000398422
  • ENSP00000381456
  • ENST00000539919
  • ENSP00000437824
  • ENST00000540468
  • ENSP00000442058

Symbol
  • CCTH
  • NIP7-1
  • CCTH
  • CCTETA
  • NIP7-1
  • TCP1ETA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
kinase perturbation
1
co-expressed gene
0.99
disease perturbation
0.97
hub protein
0.96


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 45.26   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 253   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 45.26   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 253   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
1
1
1
71.1
intelligence
1
1
0
6
25.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
1
71.1
intelligence
0
6
25.4
Pathways (9)
Association of TriC/CCT with target proteins during biosynthesis (R-HSA-390471)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Association of TriC/CCT with target proteins during biosynthesis
Reactome
Chaperonin-mediated protein folding
Reactome
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
Reactome
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding
Reactome
Folding of actin by CCT/TriC
Name
Explore in Pharos
Explore in Source
Association of TriC/CCT with target proteins during biosynthesis
Chaperonin-mediated protein folding
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding
Folding of actin by CCT/TriC
Gene Ontology Terms (17)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (494)
1 – 10 of 494
DCAF12
Tbio
Novelty: 0.15472702
p_int: 0.999999698
p_ni: 3.02e-7
Score: 0.166
Data Source: BioPlex,STRINGDB
KLHDC8B
Tbio
Novelty: 0.15409379
p_int: 0.999997858
p_ni: 0.000001842
p_wrong: 3e-7
Score: 0.315
Data Source: BioPlex,STRINGDB
WDR25
Tdark
Novelty: 0.53632123
p_int: 0.999993765
p_ni: 0.000006235
Score: 0.221
Data Source: BioPlex,STRINGDB
WDR70
Tdark
Novelty: 0.37521871
p_int: 0.9999929
p_ni: 0.0000071
Score: 0.15
Data Source: BioPlex,STRINGDB
TUBD1
Tbio
Novelty: 0.03591414
p_int: 0.999989928
p_ni: 0.000006193
p_wrong: 0.000003878
Score: 0.232
Data Source: BioPlex,STRINGDB
CCT3
Tbio
Novelty: 0.01642521
p_int: 0.999973712
p_ni: 0.000026288
Score: 0.999
Data Source: BioPlex,STRINGDB
WDR46
Tbio
Novelty: 0.19307408
p_int: 0.999967528
p_ni: 0.000032472
Score: 0.274
Data Source: BioPlex,STRINGDB
DCAF13
Tbio
Novelty: 0.02796363
p_int: 0.999958662
p_ni: 0.000041338
Score: 0.591
Data Source: BioPlex,STRINGDB
WDR24
Tdark
Novelty: 0.48411996
p_int: 0.999943505
p_ni: 0.000048492
p_wrong: 0.000008003
Data Source: BioPlex
FBXW8
Tbio
Novelty: 0.06697145
p_int: 0.999943298
p_ni: 0.0000567
p_wrong: 3e-9
Score: 0.377
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  45.26

PubMed score by year
PubTator Score  5.93

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer