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Tclin
CDK4
Cyclin-dependent kinase 4

Protein Summary
Description
Ser/Thr-kinase component of cyclin D-CDK4 (DC) complexes that phosphorylate and inhibit members of the retinoblastoma (RB) protein family including RB1 and regulate the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complexes and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also phosphorylates SMAD3 in a cell-cycle-dependent manner and represses its transcriptional activity. Component of the ternary complex, cyclin D/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex. The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic su ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000257904
  • ENSP00000257904
  • ENSG00000135446

Symbol
  • CMM3
  • PSK-J3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
chemical
1
kinase perturbation
1
interacting protein
0.99
molecular function
0.99
drug perturbation
0.96


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2425.62   (req: < 5)
Gene RIFs: 257   (req: <= 3)
Antibodies: 995   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2425.62   (req: >= 5)
Gene RIFs: 257   (req: > 3)
Antibodies: 995   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 37
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 451
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
1
1
1
46.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
1
46.3
Protein Data Bank (10)
1 – 5 of 10
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (156)
Cell Cycle (R-HSA-1640170)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 42
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell Cycle
Reactome
Cell Cycle, Mitotic
Reactome
Cellular Senescence
Reactome
Cellular responses to external stimuli
Reactome
Cellular responses to stress
Name
Explore in Pharos
Explore in Source
Cell Cycle
Cell Cycle, Mitotic
Cellular Senescence
Cellular responses to external stimuli
Cellular responses to stress
Gene Ontology Terms (48)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (441)
1 – 10 of 441
CDKN2C
Tbio
Family: Enzyme
Novelty: 0.00806886
p_int: 1
Score: 0.997
Data Source: BioPlex,Reactome,STRINGDB
OGFRL1
Tchem
Novelty: 0.35118511
p_int: 0.999999981
p_wrong: 1.9e-8
Score: 0.288
Data Source: BioPlex,STRINGDB
CDKN2B
Tbio
Family: Enzyme
Novelty: 0.00166614
p_int: 0.999999965
p_ni: 7e-9
p_wrong: 2.8e-8
Score: 0.997
Data Source: BioPlex,Reactome,STRINGDB
CCND3
Tchem
Novelty: 0.00223085
p_int: 0.999999792
p_ni: 2.08e-7
Score: 0.999
Data Source: BioPlex,STRINGDB
HSP90AB3P
Tdark
p_int: 0.999993856
p_ni: 0.000006144
Data Source: BioPlex
HSP90AB4P
Tdark
p_int: 0.999973451
p_ni: 0.000026548
Data Source: BioPlex
CDKN2A
Tbio
Family: Enzyme
Novelty: 0.00014147
p_int: 0.998876334
p_ni: 0.001123666
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
CDKN1B
Tbio
Family: Enzyme
Novelty: 0.00069449
p_int: 0.997202751
p_ni: 0.002796675
p_wrong: 5.74e-7
Score: 0.997
Data Source: BioPlex,Reactome,STRINGDB
CCND2
Tbio
Novelty: 0.00157305
p_int: 0.997043959
p_ni: 0.002956041
Score: 0.999
Data Source: BioPlex,STRINGDB
FKBP5
Tchem
Family: Enzyme
Novelty: 0.00214511
p_int: 0.996492718
p_ni: 0.003507282
Score: 0.212
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  2425.62

PubMed score by year
PubTator Score  1923.14

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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