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Tbio
LACRT
Extracellular glycoprotein lacritin

Protein Summary
Description
Modulates secretion by lacrimal acinar cells. The protein encoded by this gene is highly expressed in the lacrimal glands and localized primarily to secretory granules and secretory fluid. It augments lacrimal acinar cell secretion, promotes ductal cell proliferation, and stimulates signaling through tyrosine phosphorylation and release of calcium. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000257867
  • ENSP00000257867
  • ENSG00000135413
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.76
cell type or tissue
0.73
biological term
0.67
molecular function
0.53
cellular component
0.51


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.59   (req: < 5)
Gene RIFs: 40   (req: <= 3)
Antibodies: 26   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.59   (req: >= 5)
Gene RIFs: 40   (req: > 3)
Antibodies: 26   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 23
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein-Protein Interactions (68)
1 – 10 of 68
DDX31
Tbio
Family: Enzyme
Novelty: 2.84646195
p_int: 0.999982394
p_ni: 0.000017594
p_wrong: 1.2e-8
Data Source: BioPlex
PLXNA2
Tbio
Novelty: 0.01765957
p_int: 0.999967747
p_ni: 0.000032253
Score: 0.166
Data Source: BioPlex,STRINGDB
PCYOX1L
Tdark
Family: Enzyme
Novelty: 1.25398886
p_int: 0.99973061
p_ni: 0.00026939
Score: 0.181
Data Source: BioPlex,STRINGDB
SNX27
Tbio
Novelty: 0.02419724
p_int: 0.999640809
p_ni: 0.000359119
p_wrong: 7.2e-8
Data Source: BioPlex
HBM
Tdark
Novelty: 0.02658671
p_int: 0.998293907
p_ni: 0.001706093
Data Source: BioPlex
CCDC148
Tdark
Novelty: 2.81805259
p_int: 0.998266906
p_ni: 0.001733089
p_wrong: 4e-9
Score: 0.177
Data Source: BioPlex,STRINGDB
KCNIP4
Tbio
Family: IC
Novelty: 0.00973829
p_int: 0.998115177
p_ni: 0.001884818
p_wrong: 5e-9
Data Source: BioPlex
KATNA1
Tbio
Family: Enzyme
Novelty: 0.05656063
p_int: 0.996751361
p_ni: 0.003248639
Data Source: BioPlex
ARSK
Tbio
Family: Enzyme
Novelty: 0.11486213
p_int: 0.995746565
p_ni: 0.004253435
Score: 0.257
Data Source: BioPlex,STRINGDB
SLC25A10
Tbio
Family: Transporter
Novelty: 0.03534249
p_int: 0.995537852
p_ni: 0.004462144
p_wrong: 4e-9
Data Source: BioPlex
Publication Statistics
PubMed Score  37.59

PubMed score by year
PubTator Score  15.78

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer