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Tbio
BACH2
Transcription regulator protein BACH2

Protein Summary
Description
Transcriptional regulator that acts as repressor or activator (By similarity). Binds to Maf recognition elements (MARE) (By similarity). Plays an important role in coordinating transcription activation and repression by MAFK (By similarity). Induces apoptosis in response to oxidative stress through repression of the antiapoptotic factor HMOX1 (PubMed:17018862). Positively regulates the nuclear import of actin (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000257749
  • ENSP00000257749
  • ENSG00000112182
  • ENST00000343122
  • ENSP00000345642
  • ENST00000537989
  • ENSP00000437473

Symbol
  • BTBD25
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
0.93
phenotype
0.88
PubMedID
0.88
protein domain
0.85
transcription factor binding site profile
0.77


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 127.75   (req: < 5)
Gene RIFs: 47   (req: <= 3)
Antibodies: 222   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 127.75   (req: >= 5)
Gene RIFs: 47   (req: > 3)
Antibodies: 222   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (42)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
8
8
0
1.1
97.8
3
2
0
1.1
96.2
Eczema
2
1
0
1.1
92.8
3
2
0
1.1
91.8
eosinophil count
3
2
3
90.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
97.8
0
1.1
96.2
Eczema
0
1.1
92.8
0
1.1
91.8
eosinophil count
3
90.8
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
BTB domain and CNC homolog 2
702740
Mouse
MGI:894679
12014
Rat
RGD:1562865
313125
Dog
BTB domain and CNC homolog 2
VGNC:38361
481923
Horse
BTB domain and CNC homolog 2
VGNC:15751
100065814
Species
Name
OMA
EggNOG
Inparanoid
Macaque
BTB domain and CNC homolog 2
Mouse
Rat
Dog
BTB domain and CNC homolog 2
Horse
BTB domain and CNC homolog 2
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9BYV9-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Gene Ontology Terms (8)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (79)
1 – 10 of 79
BATF3
Tbio
Family: TF
Novelty: 0.01554987
p_int: 0.999999759
p_ni: 2.41e-7
Score: 0.41
Data Source: BioPlex,STRINGDB
FOSL2
Tbio
Family: TF
Novelty: 0.00375452
p_int: 0.999998013
p_ni: 0.000001987
Score: 0.414
Data Source: BioPlex,STRINGDB
MAFF
Tbio
Family: TF
Novelty: 0.01974936
p_int: 0.999995106
p_ni: 1.6e-8
p_wrong: 0.000004878
Score: 0.786
Data Source: BioPlex,STRINGDB
ZBTB24
Tbio
Family: TF
Novelty: 0.041401
p_int: 0.999963247
p_ni: 0.000035396
p_wrong: 0.000001357
Data Source: BioPlex
KLHL9
Tdark
Novelty: 0.22434722
p_int: 0.999847637
p_ni: 0.000149665
p_wrong: 0.000002698
Score: 0.192
Data Source: BioPlex,STRINGDB
TULP3
Tbio
Family: TF
Novelty: 0.06911636
p_int: 0.771989175
p_ni: 0.001357636
p_wrong: 0.226653189
Score: 0.196
Data Source: BioPlex,STRINGDB
PRDM1
Tbio
Family: TF; Epigenetic
Novelty: 0.00224931
Score: 0.871
Data Source: STRINGDB
MAFK
Tbio
Family: TF
Novelty: 0.01735942
Score: 0.822
Data Source: STRINGDB
PAX5
Tbio
Family: TF
Novelty: 0.0012666
Score: 0.806
Data Source: STRINGDB
MAFG
Tbio
Family: TF
Novelty: 0.01605125
Score: 0.797
Data Source: STRINGDB
Publication Statistics
PubMed Score  127.75

PubMed score by year
PubTator Score  73.25

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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