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Tbio
APC
Adenomatous polyposis coli protein

Protein Summary
Description
Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization. This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. D ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000257430
  • ENSP00000257430
  • ENSG00000134982
  • ENST00000508376
  • ENSP00000427089

Symbol
  • DP2.5
  • GS
  • DP2
  • DP3
  • BTPS2
  • DP2.5
  • PPP1R46
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
protein domain
1
hub protein
0.98
kinase
0.94
microRNA
0.94


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 542.45   (req: < 5)
Gene RIFs: 553   (req: <= 3)
Antibodies: 671   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 542.45   (req: >= 5)
Gene RIFs: 553   (req: > 3)
Antibodies: 671   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 39
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
1
2
81.3
body mass index
3
1
3
79.2
1
1
0
1.9
61.4
1
1
0
1.9
61.4
reaction time measurement
1
1
1
39.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
81.3
body mass index
3
79.2
0
1.9
61.4
0
1.9
61.4
reaction time measurement
1
39.5
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
APC, WNT signaling pathway regulator
VGNC:11810
461999
Macaque
APC, WNT signaling pathway regulator
693443
Mouse
MGI:88039
11789
Rat
RGD:2123
24205
Horse
APC, WNT signaling pathway regulator
100064431
Species
Name
OMA
EggNOG
Inparanoid
Chimp
APC, WNT signaling pathway regulator
Macaque
APC, WNT signaling pathway regulator
Mouse
Rat
Horse
APC, WNT signaling pathway regulator
Protein Structure (25 Structures, 9 AlphaFold Models)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 25
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (88)
AMER1 mutants destabilize the destruction complex (R-HSA-4839748)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 31
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
AMER1 mutants destabilize the destruction complex
Reactome
APC truncation mutants are not K63 polyubiquitinated
Reactome
APC truncation mutants have impaired AXIN binding
Reactome
AXIN missense mutants destabilize the destruction complex
Reactome
AXIN mutants destabilize the destruction complex, activating WNT signaling
Name
Explore in Pharos
Explore in Source
AMER1 mutants destabilize the destruction complex
APC truncation mutants are not K63 polyubiquitinated
APC truncation mutants have impaired AXIN binding
AXIN missense mutants destabilize the destruction complex
AXIN mutants destabilize the destruction complex, activating WNT signaling
Gene Ontology Terms (56)
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
MGI
Inferred from Physical Interaction (IPI)
CAFA
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Mutant Phenotype (IMP)
CAFA
Protein-Protein Interactions (254)
1 – 10 of 254
CTNNA3
Tbio
Novelty: 0.01472452
p_int: 0.999999036
p_ni: 9.64e-7
Score: 0.36
Data Source: BioPlex,STRINGDB
SYNC
Tbio
Novelty: 0.04605223
p_int: 0.999998436
p_ni: 0.000001564
Data Source: BioPlex
FBXW11
Tbio
Novelty: 0.0715377
p_int: 0.999995833
p_ni: 0.000004167
Score: 0.285
Data Source: BioPlex,STRINGDB
CTBP1
Tbio
Novelty: 0.00243818
p_int: 0.999992235
p_ni: 0.000007765
Score: 0.955
Data Source: BioPlex,Reactome,STRINGDB
AP2M1
Tbio
Novelty: 0.00769368
p_int: 0.999986529
p_ni: 0.000013471
Data Source: BioPlex
ZNF408
Tbio
Family: TF
Novelty: 0.10649477
p_int: 0.999841485
p_ni: 0.000158399
p_wrong: 1.16e-7
Score: 0.155
Data Source: BioPlex,STRINGDB
ACADVL
Tbio
Family: Enzyme
Novelty: 0.00383705
p_int: 0.99983188
p_ni: 0.00016812
Score: 0.183
Data Source: BioPlex,STRINGDB
BTRC
Tbio
Novelty: 0.00293475
p_int: 0.999776778
p_ni: 0.000223222
Score: 0.955
Data Source: BioPlex,Reactome,STRINGDB
TAX1BP3
Tbio
Novelty: 0.01605171
p_int: 0.999364589
p_ni: 0.000635411
Data Source: BioPlex
IQCN
Tdark
Novelty: 2.74045479
p_int: 0.997596589
p_ni: 0.002403411
Data Source: BioPlex
Publication Statistics
PubMed Score  542.45

PubMed score by year
PubTator Score  768.85

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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