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Tbio
KLB
Beta-klotho

Protein Summary
Description
Contributes to the transcriptional repression of cholesterol 7-alpha-hydroxylase (CYP7A1), the rate-limiting enzyme in bile acid synthesis. Probably inactive as a glycosidase. Increases the ability of FGFR1 and FGFR4 to bind FGF21 (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000257408
  • ENSP00000257408
  • ENSG00000134962

Symbol
  • BKL
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.73
pathway
0.66
PubMedID
0.58
cell line
0.57
cell type or tissue
0.52


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 195.69   (req: < 5)
Gene RIFs: 27   (req: <= 3)
Antibodies: 166   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 195.69   (req: >= 5)
Gene RIFs: 27   (req: > 3)
Antibodies: 166   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alcohol consumption measurement
12
8
16
8.1
99.8
alcohol use disorder measurement
2
3
1
7.7
97.7
protein intake measurement
1
1
1
74.7
bitter alcoholic beverage consumption measurement
1
1
1
62.1
lifestyle measurement
1
1
1
60.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alcohol consumption measurement
16
8.1
99.8
alcohol use disorder measurement
1
7.7
97.7
protein intake measurement
1
74.7
bitter alcoholic beverage consumption measurement
1
62.1
lifestyle measurement
1
60.5
Protein Data Bank (4)
1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (71)
Constitutive Signaling by Aberrant PI3K in Cancer (R-HSA-2219530)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 35
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Constitutive Signaling by Aberrant PI3K in Cancer
Reactome
Cytokine Signaling in Immune system
Reactome
Disease
Reactome
Diseases of signal transduction
Reactome
Downstream signaling of activated FGFR4
Name
Explore in Pharos
Explore in Source
Constitutive Signaling by Aberrant PI3K in Cancer
Cytokine Signaling in Immune system
Disease
Diseases of signal transduction
Downstream signaling of activated FGFR4
Gene Ontology Terms (14)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (64)
1 – 10 of 64
FGFR4
Tclin
Family: Kinase
Novelty: 0.00258329
Score: 0.987
Data Source: Reactome,STRINGDB
FGF19
Tbio
Novelty: 0.00317427
Score: 0.973
Data Source: Reactome,STRINGDB
FGF23
Tclin
Novelty: 0.00047318
Score: 0.963
Data Source: STRINGDB
FGFR1
Tclin
Family: Kinase
Novelty: 0.00055714
Score: 0.962
Data Source: STRINGDB
FGF21
Tbio
Novelty: 0.00111728
Score: 0.952
Data Source: STRINGDB
FRS2
Tbio
Novelty: 0.00654052
Score: 0.941
Data Source: Reactome,STRINGDB
MAPK3
Tchem
Family: Kinase
Novelty: 0.00012969
Score: 0.928
Data Source: Reactome,STRINGDB
FGF1
Tchem
Novelty: 0.00055979
Score: 0.928
Data Source: STRINGDB
MAPK1
Tchem
Family: Kinase
Novelty: 0.00061058
Score: 0.926
Data Source: Reactome,STRINGDB
FGF2
Tchem
Novelty: 0.00007856
Score: 0.92
Data Source: STRINGDB
Publication Statistics
PubMed Score  195.69

PubMed score by year
PubTator Score  29.34

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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