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Tbio
DSC1
Desmocollin-1

Protein Summary
Description
Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms. Linked to the keratinization of epithelial tissues. The protein encoded by this gene is a calcium-dependent glycoprotein that is a member of the desmocollin subfamily of the cadherin superfamily. These desmosomal family members, along with the desmogleins, are found primarily in epithelial cells where they constitute the adhesive proteins of the desmosome cell-cell junction and are required for cell adhesion and desmosome formation. A subtype of IgA pemphigus, a life-threatening autoimmune disease, is characterized by the presence of autoantibodies that target the encoded protein. The desmosomal family members are arranged in two clusters on chromosome 18. Alternative splicing of this gene r ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000257197
  • ENSP00000257197
  • ENSG00000134765
  • ENST00000257198
  • ENSP00000257198

Symbol
  • CDHF1
  • CDHF1
  • DG2/DG3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.92
interacting protein
0.78
cellular component
0.69
cell line
0.6
gene perturbation
0.59


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 60.32   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 230   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 60.32   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 230   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (6)
Developmental Biology (R-HSA-1266738)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Developmental Biology
Reactome
Formation of the cornified envelope
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Keratinization
Name
Explore in Pharos
Explore in Source
Developmental Biology
Formation of the cornified envelope
Immune System
Innate Immune System
Keratinization
Gene Ontology Terms (13)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (66)
1 – 10 of 66
PKP1
Tbio
Novelty: 0.0100609
Score: 0.992
Data Source: STRINGDB
PKP3
Tbio
Novelty: 0.0269462
Score: 0.991
Data Source: STRINGDB
DSP
Tbio
Novelty: 0.00178018
Score: 0.991
Data Source: STRINGDB
PKP2
Tbio
Novelty: 0.00493803
Score: 0.989
Data Source: STRINGDB
JUP
Tbio
Novelty: 0.0081803
Score: 0.986
Data Source: STRINGDB
EVPL
Tbio
Novelty: 0.00274279
Score: 0.956
Data Source: STRINGDB
KLK5
Tchem
Family: Enzyme
Novelty: 0.00835407
Score: 0.956
Data Source: STRINGDB
LOR
Tbio
Novelty: 0.0033781
Score: 0.954
Data Source: STRINGDB
PKP4
Tbio
Novelty: 0.03654703
Score: 0.953
Data Source: STRINGDB
PPL
Tbio
Novelty: 0.00684645
Score: 0.953
Data Source: STRINGDB
Publication Statistics
PubMed Score  60.32

PubMed score by year
PubTator Score  62.98

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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